Systolic time intervals as measures of the contractile state of the left ventricular myocardium in man.
TLDR
The results indicate that the systolic times are a valid measure of contractility which should prove useful in comparing patients with cardiac pathology confined to the LV myocardium and in following patients with extramyocardial hemodynamic lesions of constant severity.Abstract:
Previous studies relating systolic time intervals and measures of cardiac performance have suggested that the time intervals may be useful indices of myocardial contractility. To explore this possibility, systolic times and left ventricular (LV) performance and contractility were measured nearly simultaneously in 14 normal subjects and 56 patients with cardiac disease. Preejection period (PEP) and the ratio of PEP to LV ejection time (LVET) changed significantly with acute inotropic influences (exercise and isoproterenol), were normal in patients with right or left ventricular overloads in whom cardiac index and ejection fraction were depressed but contractile element velocity at peak dP/dt and the Frank-Levinson contractility index were normal, and were significantly abnormal in patients with either clinically evident or occult LV decompensation in whom the measures of contractility were reduced. Correlations of PEP and PEP/LVET with measures of both performance and contractility were insignificant for p...read more
Citations
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Plasma norepinephrine in congestive heart failure
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Noninvasive Doppler-derived myocardial performance index: Correlation with simultaneous measurements of cardiac catheterization measurements
TL;DR: This study documents that a simple, easily recordable, noninvasive Doppler index of myocardial performance correlates with invasive measurement of left ventricular systolic and diastolic function and appears to be a promisingnoninvasive measurement of overall cardiac function.
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A critical review of the systolic time intervals.
TL;DR: There is need for further studies of the clinical usefulness of the systolic time intervals to improve both diagnosis and therapy of various cardiovascular disorders.
References
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Systolic Time Intervals in Heart Failure in Man
TL;DR: It is postulated that a defect in the mechanical performance of the heart is responsible for the abnormal systolic time intervals in human heart failure.
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TL;DR: Force-velocity relations were studied in the cat papillary muscle and a characteristic relation has been demonstrated between the velocity of shortening (V) and the force deve...
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Bedside technics for the evaluation of ventricular function in man
TL;DR: Characteristic changes in the systolic intervals of the left ventricle have been demonstrated among patients with arteriosclerotic, hypertensive and primary myocardial disease and their use in the bedside evaluation of cardiac performance in man is suggested.
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The Relationship of Alterations in Systolic Time Intervals to Ejection Fraction in Patients with Cardiac Disease
TL;DR: The relationships between the systolic time intervals determined from simultaneous recordings of the electrocardiograms, the phonocardiogram, the carotid arterial pulse tracing, and direct measures of left ventricular performance as assessed angiographically by measurement of left Ventricular stroke volume and ejection fraction were studied.