Journal ArticleDOI
T1ρ‐relaxation in articular cartilage: Effects of enzymatic degradation
Umamaheswar Duvvuri,Ravinder Reddy,Saurabh D. Patel,Jonathan H. Kaufman,J B Kneeland,John S. Leigh +5 more
TLDR
The results suggest that T1ρ measurements are selectively sensitive to proteoglycan content, and the potential of this method in distinguishing the early degenerative changes in cartilage associated with osteoarthritis is discussed.Abstract:
Spin-lattice relaxation in the rotating frame (T1rho) dispersion spectroscopy and imaging were used to study normal and enzymatically degraded bovine articular cartilage. Normal specimens demonstrate significant T1rho "dispersion" (approximately 60 to approximately 130 ms) in the 100 Hz to 9 kHz frequency range. Proteoglycan-degraded specimens have 33% greater T1rho values than collagen-degraded or normal samples. T1rho-weighted images reveal structure not found in conventional T1- or T2-weighted images. Our results suggest that T1rho measurements are selectively sensitive to proteoglycan content. The potential of this method in distinguishing the early degenerative changes in cartilage associated with osteoarthritis is discussed.read more
Citations
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Journal ArticleDOI
T2 relaxation reveals spatial collagen architecture in articular cartilage: a comparative quantitative MRI and polarized light microscopic study.
Miika T. Nieminen,Jarno Rieppo,Juha Töyräs,Juhana M. Hakumäki,Johanna Silvennoinen,Mika M. Hyttinen,Heikki J. Helminen,Jukka S. Jurvelin +7 more
TL;DR: The current results reveal the close connection between the laminar T2 structure and the collagen architecture in histologic zones.
Journal ArticleDOI
In vivo T1ρ and T2 mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI
Xiaojuan Li,C. Benjamin Ma,Thomas M. Link,Darwin-Dean Castillo,Gabrielle Blumenkrantz,Jesus Lozano,Julio Carballido-Gamio,Michael D. Ries,Sharmila Majumdar +8 more
TL;DR: The ability to detect early cartilage degeneration prior to morphologic changes may allow us to critically monitor the course of OA and injury progression, and to evaluate the success of treatment to patients with early stages of Oa.
Journal ArticleDOI
Proteoglycan-induced changes in T1ρ-relaxation of articular cartilage at 4T
Sarma V.S. Akella,Ravinder R. Regatte,Alexander J. Gougoutas,Arijitt Borthakur,Erik M. Shapiro,J. Bruce Kneeland,John S. Leigh,Ravinder Reddy +7 more
TL;DR: Proteoglycan depletion‐induced changes in T1ρ (spin‐lattice relaxation in rotating frame) relaxation and dispersion in articular cartilage were studied at 4T and showed a strong correlation between changes in PG and T1RH.
Journal ArticleDOI
Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis
TL;DR: The above methodologies show great promise for elucidating the pathophysiology of various tissues and identifying risk factors of osteoarthritis, for developing structure modifying drugs (DMOADs) and for combating osteOarthritis with new and better therapy.
Journal ArticleDOI
T2 and T1ρ MRI in articular cartilage systems
TL;DR: Overall, these studies illustrate that T2 and T1ρ are sensitive to biologically meaningful changes in cartilage, however, contrary to some previous reports, they are not specific to any one inherent tissue parameter.
References
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Gd‐DTPA2− as a measure of cartilage degradation
TL;DR: Equilibration of the tissue in Gd‐DTPA2‐ gives the opportunity to directly image (through T1, weighting) the concentration of GAG, a major and critically important macromolecule in cartilage, suggesting that this technique is clinically feasible.
Journal ArticleDOI
Nuclear magnetic resonance study of the proton transfer in water
TL;DR: In this paper, the authors measured the nuclear relaxation in water and showed that the increase of relaxation rate is observable in natural water (0.037% O17), and becomes very appreciable in water enriched in O17.
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Journal ArticleDOI
Analysis of water-macromolecule proton magnetization transfer in articular cartilage.
TL;DR: It is demonstrated that the structure and concentration of the collagen matrix are the predominant determinants of the magnetization transfer process in articular cartilage with little or no contribution from proteoglycans.