Book ChapterDOI
Technetium Chemistry and Technetium Radiopharmaceuticals
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This article is published in Progress in Inorganic Chemistry.The article was published on 2007-03-09. It has received 115 citations till now. The article focuses on the topics: Pertechnetate & Technetium.read more
Citations
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The coordination chemistry of platinum anticancer drugs and related compounds with DNA
TL;DR: This chapter discusses Pt-DNA interactions, which led to the discovery of metaIIointercaIation, and the role of cis-DDP and intercaIators on DNA in the development of platinum antitumor drugs.
Book ChapterDOI
Chemistry of Thioether Macrocyclic Complexes
TL;DR: In this paper, a summary of the coordination chemistry of homoleptic thioether macrocycles is presented, with emphasis on likely future developments and uses, and some unpublished results are discussed.
Journal ArticleDOI
Evolution of Tc-99m in diagnostic radiopharmaceuticals
TL;DR: The evolution of 99mTc dating back to its discovery, the development of 99Mo/99m Tc generators, and the efforts to exploit the diverse chemistry of the element to explore a spectrum of compounds for diagnostic imaging, planar, and single photon emission computed tomography are reviewed.
Journal ArticleDOI
Single amino acid chelates (SAAC): a strategy for the design of technetium and rhenium radiopharmaceuticals.
TL;DR: This work focuses on the design of single amino acid chelates (SAACs), novel bifunctional chelators constructed from derivatized amino acids or amino acid analogues, and affords significant flexibility in the choice of donors for (99m)Tc coordination combined with the considerable advantages of routine solid phase synthetic techniques.
Journal ArticleDOI
New directions in the coordination chemistry of 99mTc: a reflection on technetium core structures and a strategy for new chelate design.
Sangeeta Ray Banerjee,Kevin P. Maresca,Lynn C. Francesconi,John F. Valliant,John W. Babich,Jon Zubieta +5 more
TL;DR: It is concluded that the single amino acid analogue chelates (SAAC), which are readily conjugated to small peptides by solid-phase synthesis methods and which form robust complexes with the {Tc(CO)3}1+ core, offer an effective alternative to the previously described methods.
References
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Journal ArticleDOI
Sites and Mechanisms of Localization of Technetium-99m Phosphorus Radiopharmaceuticals in Acute Myocardial Infarcts and other Tissues
L M Buja,A. J. Tofe,Padmakar V. Kulkarni,A. Mukherjee,Robert W. Parkey,M. D. Francis,Frederick J. Bonte,James T. Willerson +7 more
TL;DR: (99m)Tc-P uptake in acutely infarcted myocardium, and possibly other types of soft tissue damage, is limited to necrotic and severely injured cells; and in vivo studies showed that concentration of human serum albumin in infarCTedMyocardium reached a maximum of only 3.8 times normal after a circulation time of 96 h.
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Bone-seeking radionuclides: an in vivo study of factors affecting skeletal uptake.
TL;DR: Results indicate that the short-term uptake of commonly used bone-scanning agents is closely correlated with blood flow and is largely independent of the rate of osteogenesis.
Bone-seeking radionuclides: an in vivo study of factors affecting skeletal uptake
TL;DR: In this paper, the effects of alteration in blood flow and alteration in osteogenesis on the skeletal uptake of bone-seeking radionuclides in rats were investigated, and in vivo quantitative data were corroborated by the use of autoradiographic and well-counting techniques.
Journal Article
Development of New Radiopharmaceuticals Based on N-Substitution of Iminodiacetic Acid
TL;DR: These characteristics of 99mTc-labeled N-substituted iminodiacetic acids, prepared using an "instant kit" method, provide the basis for a valuable new class of radiopharmaceuticals based on bifunctional drug and biochemical analogs.