Journal ArticleDOI
Telemetry Glucose Monitoring Device With Needle-Type Glucose Sensor: A Useful Tool for Blood Glucose Monitoring in Diabetic Individuals
TLDR
Continuous glucose monitoring of five diabetic subjects for 77 ± 22 h revealed that a significant correlation existed between the subcutaneous tissue glucose concentration and the plasma glucose concentration measured simultaneously in each patient.Abstract:
For continuous monitoring of glucose concentration in ambulant diabetic patients, a telemetry glucose monitoring system with a needle-type glucose sensor has been developed. The system consists of a sensor transmitter (4 × 6 × 2 cm, 50 g) that converts current signals generated in a needle-type glucose sensor to high-frequency audio signals and a receiver that continuously calculates glucose concentrations from the received audio signals. The noise range of a monitoring record with the telemetry system (0.3 ± 0.04%, mean ± SEM) was significantly smaller than that with a wire-connected system, the wearable artificial endocrine pancreas (2.5 ± 0.3%). Postprandial tissue glucose concentration responded well to the plasma glucose concentration, with a time lag of 5 min. Continuous glucose monitoring of five diabetic subjects for 77 ± 22 h revealed that a significant correlation existed between the subcutaneous tissue glucose concentration and the plasma glucose concentration measured simultaneously in each patient. These data indicate the usefulness of the telemetry glucose monitoring system in strict glycemic control of diabetic individuals.read more
Citations
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Patent
Analyte Monitoring Device And Methods Of Use
James Say,Michael F. Tomasco,Adam Heller,Yoram Gal,Behrad Aria,Ephraim Heller,Phillip John Plante,Mark S. Vreeke,Keith A. Friedman,Fredric C. Colman +9 more
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References
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Journal ArticleDOI
Wearable artificial endocrine pancreas with needle-type glucose sensor
TL;DR: The wearable artificial endocrine pancreas, incorporating the needle-type glucose sensor, a computer calculating infusion rates of insulin, glucagon, or both, and infusion pumps, was tested in pancreatectomised dogs and produced perfect control of blood glucose for up to 7 days.
Journal ArticleDOI
Perfect Normalization of Excessive Glucagon Responses to Intravenous Arginine in Human Diabetes Mellitus With the Artificial Beta-Cell
TL;DR: It is demonstrated that the exaggerated response of A-cell secretion against arginine challenges in insulin-deficient diabetics is secondary to insulin lack, and the perfect normalization of its response is achieved only when both plasma insulin concentration and glycemie control simulate those of healthy subjects.
Journal ArticleDOI
Normalization of the Paradoxic Secretion of Glucagon in Diabetics Who Were Controlled by the Artificial Beta Cell
TL;DR: In one insulin-dependent diabetic with high anti-insulin-binding capacity, the blood glucose response after an oral glucose challenge was not normalized by the artificial beta cell and the glucagon secretion was paradoxically increased, suggesting that the paradoxic rise in glucagon, seen in response to an Oral glucose load in some diabetics, is secondary to insulin deficiency.