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Yoshimitsu Yamasaki
Researcher at Osaka University
Publications - 217
Citations - 14658
Yoshimitsu Yamasaki is an academic researcher from Osaka University. The author has contributed to research in topics: Diabetes mellitus & Insulin. The author has an hindex of 64, co-authored 212 publications receiving 13586 citations. Previous affiliations of Yoshimitsu Yamasaki include Juntendo University & Kumamoto University.
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Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.
Hideaki Kaneto,Yoshitaka Kajimoto,Jun-ichiro Miyagawa,Taka-aki Matsuoka,Yoshio Fujitani,Yutaka Umayahara,Toshiaki Hanafusa,Yuji Matsuzawa,Yoshimitsu Yamasaki,Masatsugu Hori +9 more
TL;DR: Observations indicate that antioxidant treatment can exert beneficial effects in diabetes, with preservation of in vivo beta- cell function, and provides further support for the implication of oxidative stress in beta-cell dysfunction in diabetes.
Journal ArticleDOI
Wearable artificial endocrine pancreas with needle-type glucose sensor
TL;DR: The wearable artificial endocrine pancreas, incorporating the needle-type glucose sensor, a computer calculating infusion rates of insulin, glucagon, or both, and infusion pumps, was tested in pancreatectomised dogs and produced perfect control of blood glucose for up to 7 days.
Journal ArticleDOI
Involvement of Endoplasmic Reticulum Stress in Insulin Resistance and Diabetes
Yoshihisa Nakatani,Hideaki Kaneto,Dan Kawamori,Kazutomi Yoshiuchi,Masahiro Hatazaki,Taka-aki Matsuoka,Kentaro Ozawa,Satoshi Ogawa,Masatsugu Hori,Yoshimitsu Yamasaki,Munehide Matsuhisa +10 more
TL;DR: It is shown that endoplasmic reticulum (ER) stress plays a crucial role in the insulin resistance found in diabetes by modifying the expression of oxygen-regulated protein 150 (ORP150), a molecular chaperone that protects cells from ER stress.
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Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial
W. Timothy Garvey,Ania M. Jastreboff,Carel W. le Roux,Naveed Sattar,Diego Aizenberg,Huzhang Mao,Shuyu Zhang,Nadia N. Ahmad,Mathijs C. Bunck,Imane Benabbad,Xiaotian M. Zhang,Federico C Perez Manghi,Cesar J Zaidman,Marisa Liliana Vico,Pablo R. Costanzo,Leonardo Serra,Ignacio MacKinnon,Miguel N. Hissa,M. Vidotti,José Francisco Kerr Saraiva,Bakke O Alves,Denise Reis Franco,S. Murthy,Ghanshyam Goyal,Yoshimitsu Yamasaki,Nobuyuki Sato,Satoshi Inoue,Taro Asakura,M. Shestakova,E. Khaykina,Ekaterina A. Troshina,Natalia V Vorokhobina,Alexander Ametov,Shih-Te Tu,Chwen-Yi Yang,I. Lee,Chien-Ning Huang,Horng Yih Ou,George Freeman,Sriram Machineni,K Klein,Senan Sultan,Alan A. Parsa,Alexy González,Anuj Bhargava,Susan R. Brian,Carlos Ince,Stephen Plantholt,J. Cole,Dámaris Opazo Vega,José Neuman de Souza,Jane Rohlf,Barry S. Horowitz,Rodolfo J. Galindo,Jamy D. Ard,Brian D. Curtis,Neil J. Fraser,José M. Mandry,Rizwana Mohseni,Ronald K. Mayfield,Charles B. Vance,Stephen Ong,Alexander Murray,Amer Al-Karadsheh,Tamer Yacoub,Kevin Roberts,David Fried,Julio Rosenstock,B. Bode,Juan P. Frias,Leslie J. Klaff,Ronald L. Brazg,Joanna Van,Anjanette Tan,Toby Briskin,M. J. Rhee,Tira Chaicha-Brom,Paul Hartley,L. de Nunez,Gregorio Cortes-Maisonet,G. Soucie,Stanley H. Hsia,Thomas C. Jones +82 more
TL;DR: In this 72-week trial in participants with obesity, 5 mg, 10 mg, or 15 mg of tirzepatide once weekly provided substantial and sustained reductions in body weight.
Journal ArticleDOI
Involvement of endoplasmic reticulum stress in insulin resistance and diabetes. Vol. 280 (2005) 847-851
Yoshihisa Nakatani,Hideaki Kaneto,Dan Kawamori,Kazutomi Yoshiuchi,Masahiro Hatazaki,Taka-aki Matsuoka,Kentaro Ozawa,Satoshi Ogawa,Masatsugu Hori,Yoshimitsu Yamasaki,Munehide Matsuhisa +10 more