Journal ArticleDOI
Temperature-induced phase changes in membranes of heart: a contrast between the thermal response of poikilotherms and homeotherms
TLDR
A comparison was made of the differing ability of hearts, isolated from homeothermic and poikilothermic animals, to maintain beating at low temperature, and differences were observed between the activation energy (or temperature coefficient Q 10 ) for each type of heart.Abstract:
1. 1. A comparison was made of the differing ability of hearts, isolated from homeothermic and poikilothermic animals, to maintain beating at low temperature. Over the temperature range (0–37°C) differences were observed between the activation energy (or temperature coefficient Q 10 ) for each type of heart. 2. 2. The activation energy for beat rate of the homeothermic heart dramatically increased below approximately 21·0°C. The heart beat of a poikilothermic animal maintained a constant activation energy over the full temperature range 0–37°C. 3. 3. The change in heart beat at 21°C for the homeotherm can be correlated with both temperature-induced phase changes in the lipid components of membranes, and the change in the activation energy of membrane-associated ATPases. None of these changes were observed in the membranes of the heart of the poikilotherm.read more
Citations
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Book
Warm Heart Surgery
Samuel V. Lichtenstein,Kassem A. Ashe,H. El Dalati,Robert J. Cusimano,A. Panos,Arthur S. Slutsky +5 more
TL;DR: This work has developed a novel approach to myocardial protection during cardiac operations based on these concepts, in which the chemically arrested heart is perfused continuously with blood and maintained at 37 degrees C, and suggests that continuous normothermic blood cardioplegia is safe and effective.
Journal ArticleDOI
Prospective, randomized trial of retrograde warm blood cardioplegia: myocardial benefit and neurologic threat.
Tomas D. Martin,Joseph M. Craver,John Parker Gott,William S. Weintraub,James Ramsay,Christine T. Mora,Robert A. Guyton +6 more
TL;DR: From March 1991 through July 1992, 1,001 patients having elective coronary artery bypass grafting were randomized to receive either continuous warm blood cardioplegia with systemic normothermia or intermittent cold oxygenated crystalloid cardioleongia and moderate systemic hypothermia.
Journal ArticleDOI
Warm heart surgery.
TL;DR: In this paper, the authors developed a novel approach to myocardial protection during cardiac operations based on these concepts, in which the chemically arrested heart is perfused continuously with blood and maintained at 37 degrees C. In 121 consecutive coronary bypass procedures, they have compared this approach with a historical cohort of 133 consecutive patients treated with hypothermic cardioplegia.
Journal ArticleDOI
Retrograde continuous warm blood cardioplegia: a new concept in myocardial protection.
Tomas A. Salerno,James P. Houck,Carlos A.M. Barrozo,Anthony Panos,George T. Christakis,James G. Abel,Samuel V. Lichtenstein +6 more
TL;DR: This new technique of retrograde continuous warm blood cardioplegia is a simple, safe, and reliable method of myocardial protection that may change the way the heart intraoperatively is protected.
Journal ArticleDOI
Functional properties of biological membranes: a physical-chemical approach.
TL;DR: This paper argues that doubt can only exist where there is a question only when there is an answer, and this only when something can be said.
References
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Book ChapterDOI
[7] Mitochondrial respiratory control and the polarographic measurement of ADP : O ratios
TL;DR: This chapter discusses the mitochondrial respiratory control and the polarographic measurement of ADP : O ratios and the principle of the oxygen electrode has been summarized, and the design of the vibrating oxygen electrode for use with speetrophotometric studies is illustrated.
Journal ArticleDOI
Lipid composition and permeability of liposomes.
TL;DR: Comparisons of the permeability of the liposomes of phospholipids with asymmetric chains are much more permeable than those of lecithins with chains of equal length but with the same total number of paraffin carbon atoms suggests that, certainly at lower temperatures, the model structures are muchMore permeable.
Journal ArticleDOI
Temperature-induced Phase Changes in Mitochondrial Membranes Detected by Spin Labeling
TL;DR: Molecular motion data from a spin-labeled fatty acid presented on Arrhenius graphs allow melting points or phase transitions to be inferred in local domains such as membranes and indicate that some membrane-bound enzymes are sensitive to the physical state of membrane lipids.
Journal ArticleDOI
The influence of membranes on the temperature-induced changes in the kinetics of some respiratory enzymes of mitochondria.
TL;DR: The results suggest that the temperature-induced change in activation energy of the membrane-bound enzymes is associated with a phase change in the lipid component of the membranes which induces a configurationalchange in the enzyme proteins.
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