The action of sympathetic blocking agents on isolated and innervated atria and vessels.
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A preparation is described of isolated rabbit atria with both vagus and sympathetic nerves that abolished the constrictor effect of nervous stimulation and of acetylcholine, but increased that of tyramine in the vessels of the perfused rabbit ear.Abstract:
A preparation is described of isolated rabbit atria with both vagus and sympathetic nerves. The action on it of bretylium and of choline 2,6-xylyl ether bromide (TM10) was studied. A concentration of breylium sufficient to abolish the response to sympathetic stimulation also depressed the response to vagal stimulation. The effect was reversible, though more easily with choline xylyl ether. Both drugs abolished the accelerating action of acetylcholine in the presence of atropine, but they augmented the action of tyramine, and did not reduce that of amphetamine. In the vessels of the perfused rabbit ear they abolished the constrictor effect of nervous stimulation and of acetylcholine, but increased that of tyramine.read more
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References
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The effect on the isolated rabbit heart of vagal stimulation and its modification by cocaine, hexamethonium and ouabain
TL;DR: The experiments to be described have been concerned with the effect of vagus stimulation in the isolated heart and auricles of the rabbit and the action of cocaine, of hexamethonium and of the cardiac glycoside ouabain was studied.
Journal ArticleDOI
Darenthin hypotensive agent of new type
Journal ArticleDOI
The blocking action of choline 2:6‐xylyl ether bromide on adrenergic nerves
TL;DR: Examination of some ethers related to TM 10 revealed no correlation between TM 10-like adrenergic blocking activity and local anaesthetic activity, and the action of TM 10 on adrenergic nerves does not, therefore, seem to be accounted for by axonal block.
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