Journal ArticleDOI
The aged pineal gland: reduction in pinealocyte number and adrenergic innervation in male rats.
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TLDR
It is concluded that the age-related decline in pineal metabolism may be due to both decreased parenchymal cell number and reduced sympathetic innervation.About:
This article is published in Experimental Gerontology.The article was published on 1990-01-01. It has received 15 citations till now. The article focuses on the topics: Pinealocyte & Pineal gland.read more
Citations
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Journal ArticleDOI
The role of melatonin and serotonin in aging: update.
B.R. Grad,R. Rozencwaig +1 more
TL;DR: Ageing is a syndrome of relative melatonin deficiency resulting from the gradual failure of the pineal gland, leading to a decline in adaptive processes and a predictable syndrome manifested by the "diseases of the aged" (DOA) and subsequent death of the organism.
Journal ArticleDOI
Age-related differences in serum melatonin and pineal NAT activity and in the response of rat pineal to a 50-HZ magnetic field
Brahim Selmaoui,Yvan Touitou +1 more
TL;DR: The data strongly suggest that old rats are insensitive to the magnetic field, and aging may change sensitivity of rats to a magnetic field.
Journal ArticleDOI
Diminished Pineal Function Coincides with Disturbed Circadian Endocrine Rhythmicity in Untreated Primary Cancer Patients
TL;DR: The chemical signal melatonin acts as a time-keeper for the different substructures of the body such as the endocrine and the immune system and conveys circadian and seasonal information on the timing and duration of environmental photoperiods.
Journal ArticleDOI
The Decrease of Pineal Melatonin Production with Age
Willy Humbert,Paul Pévet +1 more
TL;DR: The hypothesis of “loss of circadian rhythmicity in aging” is supported by numerous animal studies and is hypothesized that the gradual and progressive deterioration of functional potential is the result of the loss of coordination among the many interdependent oscillating systems.
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The pineal gland of the aging rat: calcium localization and variation in the number of pinealocytes.
Willy Humbert,Paul Pévet +1 more
TL;DR: There is a significant increase in the number of dark pinealocytes there is a decrease in the total number of pinealo‐cytes in aged rats, which may explain the age‐related functional decline of the pineal gland activity.
References
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Journal ArticleDOI
A methodological approach to rapid and sensitive monoamine histofluorescence using a modified glyoxylic acid technique: the SPG method.
J C Torre,J W Surgeon +1 more
TL;DR: The SPG method retains the high specific sensitivity for monoamines previously described in the original technique but is, in addition, more rapid and simple and is easily accessible as a research tool to investigators inexperienced in histofluorescence techniques.
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The development, topographical relations and innervation of the epiphysis cerebri in the albino rat.
TL;DR: The innervation of the pineal body is examined in normal adult rats as well as in a number of specimens in which both superior cervical ganglia were removed, showing topographical relations with this organ.
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Pineal melatonin rhythm: reduction in aging Syrian hamsters.
TL;DR: Melatonin content measured by radioimmunoassay of the pineal gland over a 24-hour period indicates a marked drop in pineal biosynthetic activity in the aging hamster.