Journal ArticleDOI
The development of the retina of the albino rat.
TLDR
In this paper, a quantitative analysis during development of retinal volume, thickness of the entire neural retina and thickness of each of the retinal layers, both posteriorly and peripherally, was made.Abstract:
Morphogenesis of the retina of the Sprague-Dawley albino rat was studied by light microscopy from day 11 of gestation until 225 days after birth. A quantitative analysis during development of retinal volume, thickness of the entire neural retina and thickness of each of the retinal layers, both posteriorly and peripherally, was made. The results indicate that initially a single neuroblastic layer forms and continually thickens by mitosis at its outer border. The retinal layers then form in sequence, moving from the inner retinal border outward and always beginning posteriorly and then spreading peripherally. The transient layer of Chievitz does not appear. All adult layers are present by eight days after birth and each layer thins after reaching its maximal thickness. Total thickness of the retina excluding pigmented epithelium, is greatest on postnatal day 5, but retinal volume only reaches a peak on postnatal days 7 to 12. The nerve fiber, inner plexiform, outer plexiform and bacillary layers all continue to increase in thickness after the ganglion cell and inner and outer nuclear layers reach their maximal width and are beginning to become thinner.read more
Citations
More filters
Journal ArticleDOI
The Retinal Pigment Epithelium in Visual Function
TL;DR: This review summarizes the current knowledge of RPE functions and describes how failure of these functions causes loss of visual function.
Journal ArticleDOI
Cell differentiation in the retina of the mouse
TL;DR: Cell differentiation in the retina of the mouse during the postnatal period was studied by autoradiography to determine when these cells completed their final mitosis prior to differentiating.
Journal ArticleDOI
Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia
TL;DR: It is proposed that hypoxia caused by the onset of neuronal activity is detected by strategically located populations of neuroglia, first astrocytes, then Muller cells, and in response they secrete VEGF, inducing formation of the superficial and deep layers of retinal vessels, respectively.
Journal ArticleDOI
Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer.
TL;DR: A cell-lineage marking system applicable to the vertebrate nervous system using Escherichia coli beta-galactosidase as a marker gene and demonstrating a high level of expression of this marker from the viral long terminal repeat promoter, with simultaneous expression of the Tn5 neo gene from the simian virus 40 early promoter.
Journal Article
Differential effect of the rd mutation on rods and cones in the mouse retina.
TL;DR: A central to peripheral temporal gradient of degeneration exists, such that some rod nuclei persist in the far periphery up to day 47, but none is found at day 65.
References
More filters
Book
The Vertebrate Eye and Its Adaptive Radiation
TL;DR: The new Conductivity Bridge derives its bridge source.
Journal ArticleDOI
Hereditary degeneration of the rat retina
TL;DR: The cataract is not due to a disturbance in the blood supply to the eye; the vessels of the retina and choroid were found to be healthy at the time of onset of the lens changes; the iris and ciliary body were foundto be normal.
Journal ArticleDOI
Differentiation, metabolic organization, and viability of the visual cell.
TL;DR: These studies attempt to uncover the functional and metabolic organization of the visual cell as a unit and to determine consequences of this organization with regard to visual cell disease.
Journal ArticleDOI
Differential addition of cells to the retina in Rana pipiens tadpoles.
TL;DR: Colchicine and thymidine-3H were used to determine the source and manner of distribution of the new cells added to the inner nuclear layer of the retina of Rana pipiens tadpoles.