Journal ArticleDOI
The interphotoreceptor matrix: electron microscopic and histochemical observations on the vertebrate retina.
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TLDR
Comparative fine structural investigations made on frog, chicken, rat, monkey and human retinas confirmed the presence of an amorphous intercellular substance, interphotoreceptor matrix, around the outer and inner segments of the visual cells.About:
This article is published in Experimental Eye Research.The article was published on 1970-07-01. It has received 98 citations till now. The article focuses on the topics: Interphotoreceptor matrix & Apical cytoplasm.read more
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Blood–retinal barrier in hypoxic ischaemic conditions: Basic concepts, clinical features and management
TL;DR: Clinically, anti-VEGF therapy has been shown to improve vision in diabetic maculopathy and in neovascular ARMD, and the visual benefit appears to arise from the restoration of BRB integrity with a reduction of retinal oedema.
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αB Crystallin Is Apically Secreted within Exosomes by Polarized Human Retinal Pigment Epithelium and Provides Neuroprotection to Adjacent Cells
Parameswaran G. Sreekumar,Ram Kannan,Mizuki Kitamura,Christine Spee,Ernesto Barron,Stephen J. Ryan,David R. Hinton +6 more
TL;DR: An important role for αB crystallin is demonstrated in maintaining and facilitating a neuroprotective outer retinal environment and may also explain the accumulation of α B crystallin in extracellular sub-RPE deposits in the stressed microenvironment in age-related macular degeneration.
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Distribution of cone photoreceptors in the mammalian retina.
TL;DR: It is suggested that the short‐wave sensitive cone fields in mammals are rudimentary areas conserving an ancestral stage of the photopigment evolution.
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Recent advances in the use of Sus scrofa (pig) as a model system for proteomic studies.
TL;DR: The present review will highlight some of the advantages and disadvantages of pig as a model system for proteomic studies.
Journal Article
Hyaluronan and the functional organization of the interphotoreceptor matrix.
TL;DR: This discussion will be limited to recent advances in understanding novel molecules present in the IPM; to HA and its properties that permit selfassembly into a complex matrix; and to a unifying organizational concept based on interactions between HA and HAbinding proteins located in and around the IPM.
References
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Electron microscope observations on the carbohydrate-rich cell coat present at the surface of cells in the rat.
A. Rambourg,C. P. Leblond +1 more
TL;DR: Findings indicate that the stained layer is a "cell coat" located outside the plasma membrane, since the cell coat is also stained by colloidal thorium, a technique for detection of acidic carbohydrates, this structure presumably contains not only glycoprotein but also acidic residues.
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Recent modifications of the glycol methacrylate embedding procedure.
TL;DR: A considerably improved routine method for embedding of tissues in the water-soluble plastic glycol-methacrylate (GMA) is described and the fine structural preservation of tissues is now more regular.
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Ultrastructural localization of acid mucosubstances in the mouse colon with iron-containing stains
TL;DR: Selective ultrastructural staining of acid mucosubstances in sites containing histochemically identifiable sulfo- and sialomucins has been obtained in fixed cryostat sections with both ferric chloride and colloidal iron solutions, and the optimal value was found to be approximately 2.0.
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Presence of a "cell coat" rich in carbohydrate at the surface of cells in the rat.
TL;DR: To find out whether or not mammalian cells have a surface coat, over 50 cell types were examined in rat tissues stained with the periodic acid‐Schiff technique for glycoproteins or the colloidal iron technique for acidic carbohydrates.
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Studies on plasma membranes. IV. The ultrastructural localization and content of sialic acid in plasma membranes isolated from rat liver and hepatoma.
E. L. Benedetti,P. Emmelot +1 more
TL;DR: Plasma membranes were isolated from rat liver and a transplanted rat hepatoma of the hepatocellular type and treated with colloidal iron hydroxide (CIH), which was found to react specifically with the neuraminidase-sensitive sialic acid of the liver membranes.