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Open AccessJournal ArticleDOI

The mechanism of carcinogenesis by tobacco smoke. Further experimental evidence and a prediction from the thiol-defence hypothesis.

M L Fenner, +1 more
- 01 Sep 1968 - 
- Vol. 22, Iss: 3, pp 474-479
TLDR
The mechanism of carcinogenesis by tobacco smoke is explained and a prediction from the thiol-defence hypothesis is made that tobacco smoke-related cancers are more likely to occur in women than in men.
Abstract
The mechanism of carcinogenesis by tobacco smoke. Further experimental evidence and a prediction from the thiol-defence hypothesis

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Citations
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Journal ArticleDOI

Free-radical chemistry of cigarette smoke and its toxicological implications.

TL;DR: Cigarette smoke contains two very different populations of free radicals; it is suggested that this Q/QH2 polymer is an active redox system that is capable of reducing molecular oxygen to produce superoxide, eventually leading to hydrogen peroxide and hydroxyl radicals.
Journal ArticleDOI

Molecular aspects of the mammalian cell surface

TL;DR: Radiation studies include radiosensitization, radioprotection, the involvement of sulfhydryl and amino groups, radiation and the suppression of the immune response, and radiosensitivity of lymphocytes.
Journal ArticleDOI

Cigarette smoking and oxidative damage in the lung.

TL;DR: Metabolic adaptation, such as accumulation of vitamin E in the lung, and increased activities of superoxide dismutase in alveolar macrophages and pulmonary tissues of chronically smoked animals may enable smoked subjects to counteract oxidative stress and to resist further damage to smoke exposure.
Journal ArticleDOI

The antioxidant vitamins.

TL;DR: This article is an attempt to study the metabolic functions of vitamin C and E together, and shows a number of metabolic pathways with which both vitamins interact.
Journal ArticleDOI

Repeated exposure to acrolein vapour: Subacute studies in hamsters, rats and rabbits☆

TL;DR: Rats appeared to be the most susceptible of the species examined and showed treatment-related abnormalities even at 0.4 ppm, whereas this exposure level was found to be a no-toxic effect level in both hamsters and rabbits.
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