Open AccessJournal Article
The origin of cancer
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This article is published in The Eugenics Review.The article was published on 1934-04-01 and is currently open access. It has received 375 citations till now. The article focuses on the topics: Cancer.read more
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Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.
Patrick J. Pollard,J. J. Briere,N. A. Alam,J Barwell,Ella Barclay,Noel C. Wortham,Tim Hunt,M. Mitchell,Simon E. Olpin,Stuart James Moat,Iain P. Hargreaves,S. J. Heales,Yuen-Li Chung,John R. Griffiths,A. Dalgleish,John A. McGrath,Michael Gleeson,Shirley Hodgson,Richard Poulsom,Pierre Rustin,I. P. M. Tomlinson +20 more
TL;DR: In this study, it is shown that FH-deficient cells and tumours accumulate fumarate and, to a lesser extent, succinate, and in situ analyses showed that these tumours also have over-expression of hypoxia-inducible factor 1alpha, activation of HIF1alphatargets, and high microvessel density.
Journal ArticleDOI
Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect
TL;DR: It is posited that in carcinogenesis, aberrant cell signaling due to exaggerated and continually high lactate levels yields an inappropriate positive feedback loop that increases glucose uptake, glycolysis, lactate production and release, decreases mitochondrial function and clearance and upregulates glyCOlytic enzyme and monocarboxylate transporter expression thereby supporting angiogenesis, immune escape, cell migration, metastasis and self-sufficient metabolism.
Journal ArticleDOI
The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses
TL;DR: This review intends to give a contemporary and detailed overview of the different roles of immune cells, exosomes, and molecules acting in the tumor microenvironment and how they relate to immune activation and escape.
Journal ArticleDOI
Hallmarks of glycosylation in cancer
TL;DR: How glycosylation is clearly an enabling characteristic that is causally associated with the acquisition of all the hallmark capabilities is discussed, which indicates that glycans play a role in every recognised cancer hallmark.
Journal ArticleDOI
Glucose conjugation for the specific targeting and treatment of cancer
TL;DR: This review summarizes the most salient examples of glycoconjugates, in which known cytotoxins or targeted anticancer therapeutics have been linked to glucose (or another glucose transporter substrate sugar) for improved cancer targeting and selectivity, and provides a series of guidelines for the design and mechanistic evaluation of future glycconjugates.
References
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Journal ArticleDOI
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.
Patrick J. Pollard,J. J. Briere,N. A. Alam,J Barwell,Ella Barclay,Noel C. Wortham,Tim Hunt,M. Mitchell,Simon E. Olpin,Stuart James Moat,Iain P. Hargreaves,S. J. Heales,Yuen-Li Chung,John R. Griffiths,A. Dalgleish,John A. McGrath,Michael Gleeson,Shirley Hodgson,Richard Poulsom,Pierre Rustin,I. P. M. Tomlinson +20 more
TL;DR: In this study, it is shown that FH-deficient cells and tumours accumulate fumarate and, to a lesser extent, succinate, and in situ analyses showed that these tumours also have over-expression of hypoxia-inducible factor 1alpha, activation of HIF1alphatargets, and high microvessel density.
Journal ArticleDOI
Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect
TL;DR: It is posited that in carcinogenesis, aberrant cell signaling due to exaggerated and continually high lactate levels yields an inappropriate positive feedback loop that increases glucose uptake, glycolysis, lactate production and release, decreases mitochondrial function and clearance and upregulates glyCOlytic enzyme and monocarboxylate transporter expression thereby supporting angiogenesis, immune escape, cell migration, metastasis and self-sufficient metabolism.
Journal ArticleDOI
The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses
TL;DR: This review intends to give a contemporary and detailed overview of the different roles of immune cells, exosomes, and molecules acting in the tumor microenvironment and how they relate to immune activation and escape.
Journal ArticleDOI
Hallmarks of glycosylation in cancer
TL;DR: How glycosylation is clearly an enabling characteristic that is causally associated with the acquisition of all the hallmark capabilities is discussed, which indicates that glycans play a role in every recognised cancer hallmark.
Journal ArticleDOI
Glucose conjugation for the specific targeting and treatment of cancer
TL;DR: This review summarizes the most salient examples of glycoconjugates, in which known cytotoxins or targeted anticancer therapeutics have been linked to glucose (or another glucose transporter substrate sugar) for improved cancer targeting and selectivity, and provides a series of guidelines for the design and mechanistic evaluation of future glycconjugates.