Journal ArticleDOI
The Role of Vasopressin in Blood Pressure Control and in Experimental Hypertension
TLDR
Vasopressin may play a role in normal cardiovascular homeostatic responses, but its role in the pathogenesis of one-kidney Goldblatt hypertension is unlikely to be significant.Abstract:
1. The role of vasopressin in blood pressure control and in the pathogenesis of one-kidney Goldblatt hypertension in the conscious dog was investigated. 2. Infusion of synthetic arginine vasopressin to elevate plasma levels approximately five-fold caused bradycardia in normal dogs and increase in mean arterial blood pressure in dogs with pharmacological autonomic blockade. 3. A similar degree of elevation of plasma vasopressin concentration was observed after mild non-hypotensive haemorrhage. 4. Renal artery constriction in unilaterally-nephrectomized dogs caused a rise in plasma renin activity and only a doubling of plasma vasopressin concentration, but a marked rise in mean arterial blood pressure. 5. Vasopressin may play a role in normal cardiovascular homeostatic responses, but its role in the pathogenesis of this form of hypertension is unlikely to be significant.read more
Citations
More filters
Journal ArticleDOI
Plasma and platelet vasopressin in essential hypertension and congestive heart failure.
TL;DR: It is demonstrated that platelets normally present in centrifuged plasma cause an overestimation of the plasma vasopressin levels, which is higher than the normal range in platelet-free plasma prepared by differen-tial centrifugation.
Journal ArticleDOI
Evidence and quantification of the vasopressin arterial pressure control system in the dog.
TL;DR: It appears from this study that AVP has potent systemic vasoconstrictor actions enabling it to make a significant contribution in the restoration of arterial pressure during hemorrhage.
Journal Article
Pressor responsiveness to vasopressin in the rat with DOC-salt hypertension
TL;DR: It is suggested that rasopressin is essential for the expansion of blood rolume in the early stages of DOC-salt hypertension, and functions as a direct pressor agent only in the later stages.
Journal ArticleDOI
Immunoreactive arginine vasopressin in the rat thymus.
TL;DR: The rise 2 days after adrenalectomy, and the fall 8 days later, were both prevented by administration of aldosterone, but not by corticosterone or dexamethasone to adrenalectomized animals.
Journal ArticleDOI
Blood pressure-lowering effect of an orally active vasopressin V1 receptor antagonist in mineralocorticoid hypertension in the rat.
TL;DR: Chronic oral OPC-21268 (30 mg/kg) twice daily for 7 days significantly reduced systolic blood pressure in DOCA-salt hypertension, with an average maximal decrease of 27 +/- 5 mm Hg, and the antihypertensive effect was reversed 5 days after treatment was stopped.
References
More filters
Journal ArticleDOI
Interaction of Vasopressin and the Baroreceptor Reflex System in the Regulation of Arterial Blood Pressure in the Dog
TL;DR: Decapitated, spinal, anesthetized dogs maintained with a small continuous infusion of norepinephrine exhibited the greatest sensitivity to vasopressin; the threshold dose for a pressor response was similar to that in conscious baroreceptor-denervated dogs, but pressor sensitivity at physiological dose levels was increased nearly 8, 000-fold.
Journal ArticleDOI
Stimulation of ADH release by the renin-angiotensin system.
JP Bonjour,RL Malvin +1 more
Journal ArticleDOI
Vasopressor role of ADH in the pathogenesis of malignant DOC hypertension
TL;DR: The relationship between the height of BP and plasma AVP concentration in DOC hypertensive rats indicates, when compared with that relationship in diabetes insipidus rats infused with AVP, a marked enhancement of the vasopressor effect of AVP.
Journal ArticleDOI
Plasma vasopressin concentrations and effects of vasopressin antiserum on blood pressure in rats with malignant two-kidney Goldblatt hypertension.
TL;DR: Male Sprague-Dawley rats with unilateral renal artery stenosis and a contralateral untouched kidney develop a malignant hypertension which is characterized by high blood pressures, sodium and water depletion, and subsequent activation of the renin-angiotensin system, and plasma arginine vasopressin concentrations are found 3-fold higher than those in rats with benign renal hypertension, and 4- to 5-foldHigher than Those in normotensive control rats.
Journal Article
Metabolism of angiotensin II in sodium depletion and hypertension in humans.
TL;DR: The increase in metabolic clearance rate associated with sodium depletion in normal subjects may explain the dissociation of plasma renin and plasma angiotensin in this state.