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The sequential analysis of cancer development.
Emmanuel Farber,Ross Cameron +1 more
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This chapter reviews the sequence of cellular and other changes during cancer development in selected sites in experimental animals and in humans and highlights the similarities and differences among the carcinogenic processes.Abstract:
Publisher Summary This chapter reviews the sequence of cellular and other changes during cancer development in selected sites in experimental animals and in humans. It highlights the similarities and differences among the carcinogenic processes and discusses the evident generalities and working hypotheses derived from the analyses. It also discusses some perspective concerning the possible relationship of carcinogenesis to other types of chronic pathological processes such as some forms of adaptation and evolution. Major emphasis is given to three sites—namely, skin, liver, and breast. Several other sites or types of neoplasms are also discussed in the chapter, including urinary bladder, brain, kidney, uterine cervix, and foreign-body sarcoma. It focuses on the development of cancer with chemicals in experimental animals and in humans. To date, the major evidence for a beneficial role for new cell populations occurring during the preneoplastic phase of carcinogenesis concerns the liver. However, it seems appropriate to explore other systems from this point of view. In other organs or tissues, appropriate physiological or environmental factors should be sought as possible influences on early carcinogen-induced new cell populations. These influences might well constitute naturally occurring “promoting” environments in at least some carcinogenic process.read more
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Journal ArticleDOI
A study of tumor progression: The precursor lesions of superficial spreading and nodular melanoma
Wallace H. Clark,David E. Elder,DuPont Guerry,Martin N. Epstein,Mark H. Greene,Marie Van Horn +5 more
TL;DR: Six evident lesional steps of tumor progression form the neoplastic system that affects the human epidermal melanocyte: 1) the common acquired melanocytic nevus; 2) a melanocytes with lentiginous melanocytics hyperplasia; 3) a metastatic melanoma with aberrant differentiation and melanocytical nuclear atypia; 4) the radial growth phase of primary melanoma; 5) the vertical growth phase: a growth form characteristic of metastases.
Journal Article
Mechanisms of Tumor Progression
TL;DR: It is the purpose of this brief discussion to summarize some current thoughts concerning tumor progression and suggest where present investigations may be leading.
Journal ArticleDOI
Evolution of tumours and the impact of molecular oncology.
George Klein,Eva Klein +1 more
TL;DR: Advances in molecular biology have made it possible to define some of these changes in molecular terms and to trace the steps by which certain tumours evolve.
Journal ArticleDOI
The role of hepatocytes and oval cells in liver regeneration and repopulation.
Nelson Fausto,Jean S. Campbell +1 more
TL;DR: In the liver, normally quiescent differentiated cells replicate rapidly after tissue resection, while intra-hepatic precursor cells (oval cells) proliferate and generate lineage only in situations in which hepatocyte proliferation is blocked or delayed.
Journal ArticleDOI
Glutathione Transferases and Cancer
Shigeki Tsuchida,Kiyomi Sato +1 more
TL;DR: New findings regarding the respective molecular forms involved in carcinogenesis and anticancer drug resistance are reviewed, with particular emphasis on Pi class forms in preneoplastic tissues.
References
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Journal ArticleDOI
The clonal evolution of tumor cell populations
TL;DR: Each patient's cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment, which should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer.
Book
Dermatology in general medicine
TL;DR: Introduction biology and pathophysiology of skin disorders presenting in the skin and mucous membranes dermatology and internal medicine diseases due to microbial agents therapeutics paediatric and geriatric dermatology.
Book
Histopathology of the skin
TL;DR: Histopathology of the skin is studied in detail in order to establish a clear picture of the immune response to various types of injuries.
Journal ArticleDOI
Role of cell shape in growth control
Judah Folkman,Anne Moscona +1 more
TL;DR: Cell shape was found to be tightly coupled to DNA synthesis and growth in nontransformed cells, suggesting a mechanism that is important in growth control of mammalian cells, and providing a more fundamental interpretation of such phenomena as density dependent inhibition of cell growth and anchorage dependence.