Showing papers in "Human Pathology in 1984"

TL;DR: Six evident lesional steps of tumor progression form the neoplastic system that affects the human epidermal melanocyte: 1) the common acquired melanocytic nevus; 2) a melanocytes with lentiginous melanocytics hyperplasia; 3) a metastatic melanoma with aberrant differentiation and melanocytical nuclear atypia; 4) the radial growth phase of primary melanoma; 5) the vertical growth phase: a growth form characteristic of metastases.

TL;DR: Although the prognosis is much more favorable than that for angiosarcoma, extrahepatic metastases occurred in nine of the patients in this series, and the biologic behavior of the tumor may be related in part to its matrix, which may show inflammation, dense sclerosis, and calcification.

TL;DR: The appearance of many diffuse foci suggests that local viral spread occurs via endothelial cell infection, and suggests that CMV disseminates hematogenously throughout the body, initiating necrotizing foci of infection.

TL;DR: The clinicopathologic features of a rare case of hepatic "inflammatory pseudotumor" are described and compared with those of three similar cases reported in the literature and the marked reduction in tumor size and the changing cellular composition confirmed the reactive nature of the lesion.

TL;DR: In 112 unselected autopsies of adult patients without known pancreatic disease (except adult-onset diabetes mellitus), the pancreas was examined to establish the incidence and degree of such minor pancreatic lesions as lipomatosis, fibrosis, alterations of ducts and ductal epithelium, inflammatory infiltrates, focal necrosis, acinar dilation, and vascular changes.

TL;DR: The pancreases of 17 patients who had cystic fibrosis with and without diabetes mellitus were evaluated at autopsy by routine staining and immunohistochemical methods for insulin, glucagon, somatostatin, and pancreatic polypeptide.

TL;DR: The hypothesis that a totipotent primitive cell serves as the common precursor for squamous cell, adeno-, and small cell carcinoma of the esophagus, and the hypothesis can also be applied to lung cancer is supported.

TL;DR: It is concluded that immunocytochemical staining with antibodies to NSE is a practical and reliable method for distinguishing neuroblastomas from other nonneural round-cell tumors in children, even for the most primitive forms of neuroblastoma, in which morphologic techniques are less reliable.

TL;DR: The results suggest that differentiated thyroid carcinoma can be regarded as a continuous spectrum of tumor types, with pure follicular carcinomas and classic medullary carcinoma representing the two extremes and the tumors with biphasic features representing a broad intermediate group.

TL;DR: Nine cases of malignant "triton" tumors, based on the coexistence of rhabdomyoblasts and Schwann cell elements, were analyzed clinicopathologically and immunocytochemically and suggest that malignant 'tritOn' tumors may not be as rare as previously believed.

TL;DR: The most frequent cause of a pseudotail in a series of ten cases obtained from the literature was an anomalous prolongation of the coccygeal vertebrae, and additional lesions included two lipomas, and one each of teratoma, chondromegaly, glioma, and a thin, elongated parasitic fetus.

TL;DR: Necropsies were performed in 12 patients who fulfilled the CDC criteria for acquired immunodeficiency syndrome (AIDS), and the postmortem findings were compared with the premortem diagnoses, finding necropsy is a valuable tool for recognizing clinically undiagnosed infections and malignant disorders in AIDS.

TL;DR: There are no "benign" or "malignant" microcalcifications; however, the presence of weddellite is a strong indication that a lesion is benign or, at most, an in situ lobular carcinoma.

TL;DR: It is suggested that these lymphomas arise from bronchus-associated lymphoid tissue, which would explain both their histologic features and their tendency to remain localized to the lung for long periods.

TL;DR: The results complement earlier immunologic studies and add enzyme histochemical data that strongly support the concept of histiocytosis X as a proliferative disorder of cells of Langerhans lineage.

TL;DR: Evidence is provided that the swollen, granular, eosinophilic epithelial cells that compose CCP are true oncocytes that arise primarily, or perhaps exclusively, from the respiratory (Schneiderian) epithelium of the sinonasal passages rather than from minor salivary glands.

TL;DR: Findings indicate that monoclonal antibodies against intermediate filament proteins such as neurofilaments and glial filaments retain their specificity and sensitivity when employed in paraffin sections in conjunction with the peroxidase-antiperoxidases method.

TL;DR: The findings support the notion that the scarring associated with pulmonary neoplasia appears to be a host response to the tumor.

TL;DR: The identification of keratin proteins may be helpful in the pathologic diagnosis of synovial sarcoma, particularly the spindle cell monophasic variant.

TL;DR: The results strongly suggest that the presence of protease inhibitors in gastric carcinomas is related to the invasive growth of the tumors and that AAT is a tissue tumor marker of well-differentiated adenocarcinomas of the stomach.

TL;DR: It is proposed that the comparatively high frequency of mandibular involvement by intraosseous schwannoma may be related to the fact that schwANNomas, in general, arise most frequently in the head and neck regions.

TL;DR: Morphologic criteria for the diagnosis of renal oncocytoma, including ultrastructural demonstration of cytoplasmic filling by mitochondria, are presented.

TL;DR: Patients with neurofibromatosis are also at risk for developing poorly differentiated stromal tumors, resembling leiomyomas by light microscopy, which may show only characteristic cytoplasmic differentiation of smooth muscle cells after ultrastructural examination of many sections.

TL;DR: In this article, the frequency of apocrine differentiation in breast carcinomas, assessed on purely morphologic grounds, is controversial, and the authors use an immunohistochemical method for the detection of GCDFP-15, a protein present in apocrine epithelium and in the fluid of tension cysts of the breast.

TL;DR: Based on differences in immunohistochemical staining, the tumors appear to be unrelated to diffuse malignant mesotheliomas, including subpleural connective tissue.

TL;DR: An autopsy study of 60 patients with fungal infections of the heart was undertaken, finding that patients who had undergone cardiac surgery had a higher incidence of endocarditis, with Candida being the most frequent cause.

TL;DR: The distinction between the rare allergic granulomatous prostatitis, as a reflection of a more generalized allergic reaction, and both post-transurethral resection granulomas and nonspecific granulmatous prostateitis is important, given the differences in clinical outcome and treatment.

TL;DR: In this group of highly selected patients with epicardial coronary arteries disease, the histopathologic profile of the diabetic myocardium did not include distinctive abnormalities sufficient to warrant the designation of "diabetic cardiomyopathy," indicating that coronary arterial bypass grafting can be recommended for the diabetic patient who requires this procedure.

TL;DR: This case provides one more example of the coexistence of carcinoma and carcinoid in the same neoplasm and thereby supports the hypothesis that a malignantly transformed stem cell can differentiate in both epithelial and amine precursor uptake and decarboxylation directions.

TL;DR: A remarkable morphologic diversity among the endocrine-paracrine cells of the prostate and prostatic urethra was found in this study, suggesting that they play an important role in both normal and pathologic conditions.