Journal ArticleDOI
The story of Bioglass
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TLDR
The 40 year history of the development of bioactive glasses is reviewed, with emphasis on the first composition, 45S5 Bioglass®, that has been in clinical use since 1985, and the steps of discovery, characterization, in vivo and in vitro evaluation, clinical studies and product development are summarized along with the technology transfer processes.Abstract:
Historically the function of biomaterials has been to replace diseased or damaged tissues. First generation biomaterials were selected to be as bio-inert as possible and thereby minimize formation of scar tissue at the interface with host tissues. Bioactive glasses were discovered in 1969 and provided for the first time an alternative; second generation, interfacial bonding of an implant with host tissues. Tissue regeneration and repair using the gene activation properties of Bioglass® provide a third generation of biomaterials. This article reviews the 40 year history of the development of bioactive glasses, with emphasis on the first composition, 45S5 Bioglass®, that has been in clinical use since 1985. The steps of discovery, characterization, in vivo and in vitro evaluation, clinical studies and product development are summarized along with the technology transfer processes.read more
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Review of bioactive glass: from Hench to hybrids.
TL;DR: The paper takes the reader from Hench's Bioglass 45S5 to new hybrid materials that have tailorable mechanical properties and degradation rates, covering the importance of control of hierarchical structure, synthesis, processing and cellular response in the quest for new regenerative synthetic bone grafts.
Journal ArticleDOI
Bone grafts and biomaterials substitutes for bone defect repair: A review.
Wenhao Wang,Kelvin W.K. Yeung +1 more
TL;DR: The currently available bone grafts and bone substitutes as well as the biological and bio-inorganic factors for the treatments of bone defect are reviewed.
Journal ArticleDOI
Bioactive Glass and Glass-Ceramic Scaffolds for Bone Tissue Engineering
TL;DR: Current knowledge on porous bone tissue engineering scaffolds on the basis of melt-derived bioactive silicate glass compositions and relevant composite structures is reviewed and discussed.
Journal ArticleDOI
3D bioactive composite scaffolds for bone tissue engineering.
Gareth Turnbull,Jon Clarke,Frederic Picard,Frederic Picard,Philip Riches,Luanluan Jia,Fengxuan Han,Bin Li,Wenmiao Shu +8 more
TL;DR: This review will consider the ideal properties of bioactive composite 3D scaffolds and examine recent use of polymers, hydrogels, metals, ceramics and bio-glasses in BTE.
Journal ArticleDOI
Bioceramics: Past, present and for the future
TL;DR: There have been a number of major advances made in the field of bioactive ceramics, glasses and glass-ceramics during the past 30-40 years.
References
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Journal ArticleDOI
Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal ArticleDOI
Bonding mechanisms at the interface of ceramic prosthetic materials
TL;DR: A theoretical model to explain the interfacial bonding is based upon in-vitro studies of glass-ceramic solubility in interfacial hydroxyapatite crystallization mechanisms, compared with in- vivo rat femur implant histology and ultrastructure results.