The use of gamma globulin in infection refractory to antibiotics.

Cryptococcosis (torulosis). Current concepts and therapy.

A study was instituted to determine the effectiveness of γ-globulin as adjunctive therapy against infections occurring in patients with acute leukemia. Forty-six patients experienced 62 episodes of fever and were randomly assigned to receive either antibiotics and γ-globulin (treatment group) or antibiotics alone (control group). Infection was eradicated in 20 episodes in the treatment group and in 24 of the control group. The incidence of superinfection was similar in both groups. No significant benefit was derived from the routine use of γ-globulin in fevers occurring in acute leukemia.

https://jamanetwork.com/HttpHandlers/ArticlePdfHandler.ashx?journal=JAMA&articleId=1165934&pdfFileName=jama_190_13_002.pdf

Use of Gamma Globulin in Infection in Acute-Leukemia Patients.

https://acsjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/1097-0142%28196203/04%2915%3A2%3C307%3A%3AAID-CNCR2820150214%3E3.0.CO%3B2-8

A clinical and pathological study of resistance to infection in chronic lymphatic leukemia.

Gamma globulin. Studies on the antibacterial properties of pooled human gamma globulin.

Yotis, W. W. (Loyola University Medical School, Chicago, Ill.). Effect of the antibacterial serum factor on staphylococcal infections. J. Bacteriol. 83:137–143. 1962—Intracerebral injections of mice with 1 to 5 × 106 washed viable cells previously exposed for 1 hr at 4 C to 2 mg/ml of the serum factor resulted in 0 to 30% mortality when three recent isolates of yellow, hemolytic, coagulase-positive strains of Staphylococcus aureus were used. Mice inoculated in the same manner with the above strains, but exposed to an inactive preparation of the serum factor, showed a 60 to 90% mortality.

Addition of partially purified coagulase to the serum factor neutralized the protective action of the serum factor.

The serum factor was found primarily in the supernatant obtained following 62% (NH4)2SO4 saturation of the water-soluble globulin portion and precipitated by one-half volume of undiluted 95% ethanol. Plate counts, manometric techniques, and animal protection studies were employed to follow purification of the serum factor. If dry weight is taken as the criterion of purification, the active substance showed a 40-fold purification over a previous preparation of this substance.

The use of gamma globulin in infection refractory to antibiotics.

Citations

Cryptococcosis (torulosis). Current concepts and therapy.

Use of Gamma Globulin in Infection in Acute-Leukemia Patients.

A clinical and pathological study of resistance to infection in chronic lymphatic leukemia.

Gamma globulin. Studies on the antibacterial properties of pooled human gamma globulin.

Effect of the antibacterial serum factor on staphylococcal infections.

Related Papers (2)

Synergism between human gamma globulin and chloramphenicol in the treatment of experimental bacterial infections.

The treatment of bacterial infections with the combination of antibiotics and gamma globulin.