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The use of Rauwolfia serpentina in hypertensive patients.
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Rauwolfia serpentina has been used in India for many years to treat a variety of diseases that at first thought appear to bear little similarity to one another, but on reflection these various diseases could have a common denominator if they were all relieved symptomatically by a sedative or a "relaxing" drug such as Rau wolfia.Abstract:
RAUWOLFIA serpentina (Ophioxylon serpentinum) has been used in India for many years to treat a variety of diseases that at first thought appear to bear little similarity to one another. These include insanity, epilepsy, insomnia, hysteria, eclampsia and hypertension. On reflection, however, these various diseases could have a common denominator if they were all relieved symptomatically by a sedative or a "relaxing" drug such as Rauwolfia. Our attention was drawn to the drug because reports of its hypotensive effects seemed to be fairly well documented; indeed, the conservative claims made for it by several authors increased rather than . . .read more
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The Hypertension Paradox — More Uncontrolled Disease despite Improved Therapy
TL;DR: In the 2009 Shattuck Lecture, Aram Chobanian lays out the basis of an apparent paradox: despite better recognition and treatment, the prevalence of untreated hypertension continues to increase.
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Mental depression in hypertensive patients treated for long periods with large doses of reserpine.
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Journal ArticleDOI
A clinical trial of rauwolfia serpentina in essential hypertension
TL;DR: Evans and Loughnan, after a critical analysis and trial of thirty three different preparations in seventy cases of high blood pressure (essential hypertension), were forced to admit the uselessness of them all.
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New drug therapies in arterial hypertension.
TL;DR: Drugs and procedures for the treatment of essential hypertension of necessity must be nonspecific in nature, since the etiology of this disease is unknown.