Journal ArticleDOI
Theory of Oscillating Reactions
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This article is published in ChemInform.The article was published on 1990-07-24. It has received 67 citations till now.read more
Citations
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Computational systems biology
TL;DR: The reviews in this Insight cover many different aspects of this energetic field, although all, in one way or another, illuminate the functioning of modular circuits, including their robustness, design and manipulation.
Book
The Regulation of Cellular Systems
TL;DR: The basic equations of metabolic control analysis are rewritten in terms of co-response coefficients and internal response coefficients to describe the interaction of optimization methods and the interrelation with evolution.
Journal ArticleDOI
Design principles of biochemical oscillators.
Bela Novak,John J. Tyson +1 more
TL;DR: Four general requirements for biochemical oscillations are discussed: negative feedback, time delay, sufficient 'nonlinearity' of the reaction kinetics and proper balancing of the timescales of opposing chemical reactions.
Journal ArticleDOI
Modelling of simple and complex calcium oscillations
TL;DR: This review provides a comparative overview of recent developments in the modelling of cellular calcium oscillations and suggests suggestions concerning the physiological significance of oscillatory behaviour in intra- and intercellular signalling.
Journal ArticleDOI
The smallest chemical reaction system with bistability
TL;DR: It is argued that prevention of explosion is a third general necessary condition for bistability, which is so far lacking discussion in the literature, and a simple general method to design such systems is presented.
References
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Journal ArticleDOI
Computational systems biology
TL;DR: The reviews in this Insight cover many different aspects of this energetic field, although all, in one way or another, illuminate the functioning of modular circuits, including their robustness, design and manipulation.
Book
The Regulation of Cellular Systems
TL;DR: The basic equations of metabolic control analysis are rewritten in terms of co-response coefficients and internal response coefficients to describe the interaction of optimization methods and the interrelation with evolution.
Journal ArticleDOI
Design principles of biochemical oscillators.
Bela Novak,John J. Tyson +1 more
TL;DR: Four general requirements for biochemical oscillations are discussed: negative feedback, time delay, sufficient 'nonlinearity' of the reaction kinetics and proper balancing of the timescales of opposing chemical reactions.
Journal ArticleDOI
Modelling of simple and complex calcium oscillations
TL;DR: This review provides a comparative overview of recent developments in the modelling of cellular calcium oscillations and suggests suggestions concerning the physiological significance of oscillatory behaviour in intra- and intercellular signalling.
Journal ArticleDOI
The smallest chemical reaction system with bistability
TL;DR: It is argued that prevention of explosion is a third general necessary condition for bistability, which is so far lacking discussion in the literature, and a simple general method to design such systems is presented.