Patent
Therapeutic agent for tissue damage
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TLDR
In this article, the authors defined a therapeutic agent for tissue damage, the therapeutic agent containing at least one selected from the group consisting of IL-1R1 function inhibitors, IL- 1R1 expression inhibitors, MyD88 function inhibitors and myD88 expression inhibitors.Abstract:
Provided is a therapeutic agent for tissue damage. A therapeutic agent for tissue damage, the therapeutic agent containing at least one selected from the group consisting of IL-1R1 function inhibitors, IL-1R1 expression inhibitors, MyD88 function inhibitors, and MyD88 expression inhibitors.read more
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Journal ArticleDOI
Disruption of Interleukin-1 Signaling Improves the Quality of Wound Healing
Alan A. Thomay,Jean M. Daley,Edmond Sabo,P.J. Worth,Leslie J. Shelton,Mark W. Harty,Jonathan S. Reichner,Jorge E. Albina +7 more
TL;DR: It is suggested that pharmacological interference with IL-1 signaling could have therapeutic value in the prevention of hypertrophic scarring and in the treatment of fibrotic diseases.
Journal ArticleDOI
Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration
Mikaël M. Martino,Kenta Maruyama,Gisela A. Kuhn,Takashi Satoh,Osamu Takeuchi,Osamu Takeuchi,Ralph Müller,Shizuo Akira +7 more
TL;DR: It is shown that IL-1R1/MyD88 signalling negatively regulates bone regeneration, in the mouse, and a MSC delivery system integrating inhibitors of IL-2β/GSK-3β/β-catenin pathway is engineered, demonstrating that this approach may be useful in regenerative medicine applications.
Journal ArticleDOI
Role of MyD88 in TLR agonist-induced functional alterations of human adipose tissue-derived mesenchymal stem cells
TL;DR: Results suggest that TLR signaling is mediated via MyD88-independent pathways as well as MyD 88-dependent pathways in hASCs and that MyD87 contributes to the regulation of cell proliferation and differentiation in h ASCs.
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