Open AccessJournal Article
Tolerance towards glyceryl trinitrate (trinitrin) in dogs.
Bogaert Mg,De Schaepdryver Af +1 more
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This article is published in Archives internationales de pharmacodynamie et de thérapie.The article was published on 1968-01-01 and is currently open access. It has received 47 citations till now. The article focuses on the topics: Drug tolerance.read more
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Oral Isosorbide dinitrate in angina pectoris: Comparison of duration of action and dose-response relation during acute and sustained therapy
TL;DR: During sustained therapy with isosorbide dinitrate, partial tolerance to the antianginal and circulatory effects develops rapidly, and in most patients, near maximal improvement in exercise tolerance occurred after a dose of 15 or 30 mg four times daily.
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Nitric oxide donors: novel cancer therapeutics (review).
TL;DR: Classic nitric oxide donors are discussed and their potential therapeutic roles as cytotoxic agents or chemo-radio or -immune-sensitizing compounds in the treatment of drug-resistant cancers are discussed.
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Tolerance towards nitroglycerin, induced in vivo, is correlated to a reduced cGMP response and an alteration in cGMP turnover.
TL;DR: The suggestion that cGMP acts as a mediator of GTN-induced vascular smooth muscle relaxation is supported, as demonstrated in this study.
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Nitrate tolerance, rebound, and their clinical relevance in stable angina pectoris, unstable angina, and heart failure
TL;DR: Tolerance towards the beneficial effects of nitrates on hemodynamics and on exercise performance also develops rapidly during continuous or long-term nitrate therapy, and for these reasons nitrates are not used as first-line therapy to treat chronic heart failure.
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Phenomenon of nitrate tolerance
TL;DR: Nitrate tolerance is a real entity, but the clinical importance of this phenomenon remains controversial, and further investigation will need to address quality-of-life issues and perhaps assess relief of ischemia by other means.