Treatment of falciparum malaria from Vietnam with a phenanthrene methanol (WR 33063) and a quinoline methanol (WR 30090).
TLDR
Two new investigational antimalarial drugs developed by the U.S. Army Malaria Research Program were tested in patients with multi-drug-resistant falciparum malaria from Vietnam and cured 13 patients treated in the United States and 23 of 26 patients in Vietnam.Abstract:
Two new investigational antimalarial drugs developed by the U.S. Army Malaria Research Program were tested in patients with multi-drug-resistant falciparum malaria from Vietnam. WR 33063, a phenanthrene methanol, cured 13 patients treated in the United States. All of these patients had suffered multiple recrudescences after treatment with standard antimalarial drugs. In addition, 23 of 25 patients with acute attacks of falciparum malaria treated in Vietnam were cured. The rate of clinical response was prompt. WR 30090, a quinoline methanol, similarly cured eight patients with multiple recrudescences in the United States and 23 of 26 patients in Vietnam. Adverse effects associated with the drugs were not seen. These drugs signify a major advance in the chemotherapy of drug-resistant falciparum malaria.read more
Citations
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Journal ArticleDOI
Report of a WHO Scientific Group (Part 3 of 3)
K. Holubar,N.R. Bergquist,G.R. Lesser,E.H. Beutner,S. Kawachi-Takahashi,K. Tanaka,H. Kohno,M. Takahashi,Anne B. Wilson,R.R.A. Coombs,J.F. Kelly,Roy Patterson,A. Mates,T. Hallberg,B.W. Gurner,S. Thunold,J.B. Hay +16 more
Journal ArticleDOI
Mefloquine (WR 142,490) in the treatment of human malaria
TL;DR: The marked activity of a single dose of mefloquine against chloroquine-resistant strains of Plasmodium falciparum suggests that this agent may be more useful than currently available drugs are for the treatment of drug-resistant malaria.
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Infections with Plasmodium falciparum and Plasmodium vivax in the owl monkey--model systems for basic biological and chemotherapeutic studies.
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Antimalarial Activities of Various 4-Quinolinemethanols with Special Attention to WR-142,490 (Mefloquine)
TL;DR: Pilot appraisals of the activities of a selected group of 4-quinolinemethanols against acute Plasmodium falciparum infections in owl monkeys indicated that compounds of this class are equally active against infections with chloroquine-resistant and chloroquinesusceptible strains and that this efficacy is not compromised by concomitant resistance to pyrimethamine.
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Enhancement of bioavailability of a hydrophobic amine antimalarial by formulation with oleic acid in a soft gelatin capsule
TL;DR: The relative availability of the orally administered hydrophobic antimalarial alpha-(dibutylaminomethyl)-6,8-dichloro-2-(3',4'-dich chlorophenyl)-4-quinolinemethanol from two dosage forms was determined in beagle dogs.
References
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Journal ArticleDOI
Report of a WHO Scientific Group (Part 3 of 3)
K. Holubar,N.R. Bergquist,G.R. Lesser,E.H. Beutner,S. Kawachi-Takahashi,K. Tanaka,H. Kohno,M. Takahashi,Anne B. Wilson,R.R.A. Coombs,J.F. Kelly,Roy Patterson,A. Mates,T. Hallberg,B.W. Gurner,S. Thunold,J.B. Hay +16 more
Journal ArticleDOI
Malaria: Host-Defense Mechanisms and Complications
TL;DR: The importance of specific diagnosis needs emphasis in relation to the increased prevalence of malaria at civilian medical facilities in the United States and in considering host-defense mech...
Journal ArticleDOI
A Quinoline Methanol (WR 30090) for Treatment of Acute Malaria
D. C. Martin,D. C. Martin,J. D. Arnold,J. D. Arnold,D. F. Clyde,D. F. Clyde,M. Al Ibrahim,M. Al Ibrahim,P. E. Carson,P. E. Carson,Rieckmann Kh,Rieckmann Kh,D. Willerson,D. Willerson +13 more
TL;DR: WR 30090 at a dose of 230 mg every 8 hr for 6 days has proven to be a safe, well-tolerated compound with photosensitivity proving to beA minor consideration.
Journal ArticleDOI
A Phenanthrene Methanol (WR 33063) for Treatment of Acute Malaria
J. D. Arnold,D. C. Martin,D. C. Martin,P. E. Carson,P. E. Carson,Rieckmann Kh,Rieckmann Kh,D. Willerson,D. Willerson,D. F. Clyde,D. F. Clyde,R. M. Miller,R. M. Miller +12 more
TL;DR: At a dose level of 1.6 g in four divided doses for 6 days, WR 33063 cured 18 of 23 nonimmune volunteers infected with the Smith strain of Plasmodium falciparum from Vietnam, and the African Uganda I strain of chloroquine-responsive malaria was even more responsive toWR 33063.
Journal ArticleDOI
Prophylactic Activity of a Phenanthrene Methanol (WR 33063) and a Quinoline Methanol (WR 30090) in Human Malaria
TL;DR: WR 33063 did not interfere with early development of infection, but WR 30090 given for 8 weeks provided suppressive cures in 20 of 26 men, and most of the remainder experienced malaria after completion of the prophylactic course.