Journal ArticleDOI
Unusual Androgen Sensitivity of the Androgen-Independent Dunning R-3327-G Rat Prostatic Adenocarcinoma: Androgen Effect on Tumor Cell Loss
John E. Humphries,John T. Isaacs +1 more
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TLDR
The results suggest that G tumor cells are sensitive to either testosterone or DHT but that in untreated intact hosts little DHT is formed by the tumor cells.About:
This article is published in The Journal of Urology.The article was published on 1983-12-01. It has received 32 citations till now. The article focuses on the topics: Dihydrotestosterone & Androgen.read more
Citations
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Journal ArticleDOI
Antagonistic effect of androgen on prostatic cell death
TL;DR: The results suggest that the rapid involution of the prostate following castration is predominantly due to a decreased antagonistic effect of androgen on prostatic cell death rather than to a Decreased agonisticEffect of androgens on prostate cell proliferation and that these two androgenic effects are distinct processes in the prostate.
Journal Article
Expression of bcl-2 and the progression of human and rodent prostatic cancers.
TL;DR: The data demonstrate that the development of androgen independence and/or metastatic ability can be associated with the expression of bcl-2 protein but that b cl-2-independent mechanisms also exist for such progression.
Journal ArticleDOI
An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol
TL;DR: It is demonstrated that change(s) in ER-mediated gene expression rather than the amino acid sequence of the ER itself may be associated with the development of at least one form of antiestrogen resistance.
Journal ArticleDOI
The process of malignant progression in human breast cancer
TL;DR: Comparisons with MCF-7 variants strongly suggest that the factors contributing to perturbations in antiestrogen sensitivity, hormone-dependent growth, metastatic potential and tumorigenicity are essentially independent of each other and acquired in a random manner.
Journal ArticleDOI
Determination of growth fraction in advanced prostate cancer by Ki-67 immunostaining and its relationship to the time to tumor progression after hormonal therapy.
Marcus V. Sadi,Evelyn R. Barrack +1 more
TL;DR: Ki‐67 immunostaining was not accurate to predict the time to progression in individual patients undergoing hormonal therapy, and the possibility that tumor proliferation rates might predict tumor behavior for these patients was investigated.
References
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Journal ArticleDOI
Antagonistic effect of androgen on prostatic cell death
TL;DR: The results suggest that the rapid involution of the prostate following castration is predominantly due to a decreased antagonistic effect of androgen on prostatic cell death rather than to a Decreased agonisticEffect of androgens on prostate cell proliferation and that these two androgenic effects are distinct processes in the prostate.
Journal Article
Expression of bcl-2 and the progression of human and rodent prostatic cancers.
TL;DR: The data demonstrate that the development of androgen independence and/or metastatic ability can be associated with the expression of bcl-2 protein but that b cl-2-independent mechanisms also exist for such progression.
Journal ArticleDOI
An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol
TL;DR: It is demonstrated that change(s) in ER-mediated gene expression rather than the amino acid sequence of the ER itself may be associated with the development of at least one form of antiestrogen resistance.
Journal ArticleDOI
The process of malignant progression in human breast cancer
TL;DR: Comparisons with MCF-7 variants strongly suggest that the factors contributing to perturbations in antiestrogen sensitivity, hormone-dependent growth, metastatic potential and tumorigenicity are essentially independent of each other and acquired in a random manner.
Journal ArticleDOI
Determination of growth fraction in advanced prostate cancer by Ki-67 immunostaining and its relationship to the time to tumor progression after hormonal therapy.
Marcus V. Sadi,Evelyn R. Barrack +1 more
TL;DR: Ki‐67 immunostaining was not accurate to predict the time to progression in individual patients undergoing hormonal therapy, and the possibility that tumor proliferation rates might predict tumor behavior for these patients was investigated.
Related Papers (5)
A wide range of sensitivities to androgens develops in cloned Shionogi mouse mammary tumor cells.
Fernand Labrie,R. Veilleux +1 more