Showing papers in "Molecular and Cellular Endocrinology in 1992"

TL;DR: Although testosterone and dihydrotestosterone may influence the expression of other genes differently, these findings are compatible with a model system in which the differential effects can be explained as a consequence of different binding affinities to the receptor.

TL;DR: The FSH-responsive CHO and Y-1 cell lines may be suitable for the development of better in vitro FSH bioassays and constitute a convenient source of human FSH receptor protein for use in radioreceptor assays and in studies of receptor-ligand interactions.

TL;DR: Electrophysiological studies with Xenopus oocytes and transfection of the cDNA into COS-1 cells, have shown that the 2.2 kb cDNA clone encodes a functional receptor, and at the amino acid level, the rat GnRH-R shows considerable homology with that of the mouse.

TL;DR: It is demonstrated that change(s) in ER-mediated gene expression rather than the amino acid sequence of the ER itself may be associated with the development of at least one form of antiestrogen resistance.

TL;DR: Examination of the distribution of prolactin and growth hormone receptor transcripts at mid-pregnancy by semi-quantitative reverse transcriptase polymerase chain reaction showed that both are widespread in bovine fetal and placental tissues.

TL;DR: The biosynthesis of clusterin, alpha 2-macroglobulin, and testins by Sertoli cells in vitro using pulse-chase labeling analysis is demonstrated and the complicated regulatory processes involved in cell-cell interactions in the seminiferous epithelium are revealed.

TL;DR: The present results indicate that in Sertoli cells and LNCaP cells, hormonal effects on AR gene transcription play a role in regulation of AR expression, however, AR Gene transcription in these cells is differentially regulated.

TL;DR: This study investigates further PBR action by examining its subcellular localization in mouse adrenal gland using anti-peptide PBR antiserum and employing biotin-streptavidin peroxidase immunocytochemistry.

TL;DR: expression of two activin receptor mRNAs was observed, in testes of immature and mature rats, suggesting that activin has multiple actions in the control of testicular function.

TL;DR: Both promoter elements seem to be still under tissue specific control, since neither LH receptor nor FSH receptor promoter activity was detectable in another cell line (CHO) investigated.

TL;DR: Estradiol acts directly upon alpha T3-1 cells not only to reduce GnRH receptor number, but also to reduce the efficiency of coupling of residual GnRH receptors to second messenger generation.

TL;DR: The cDNA cloning and expression of PRL from normal human thymocytes support the hypothesis that PRL is a T cell-derived cytokine.

TL;DR: Eight different sequence variants diverging in the 5'-untranslated regions beginning 12 base pairs upstream from the initiating ATG codon were found and appeared to represent unspliced or partially spliced forms of GHR mRNA.

TL;DR: It is demonstrated that AT1 receptor mediates the regulatory actions of AII in the adrenal zona glomerulosa.

TL;DR: It is shown that the mouse submandibular gland (SMG) expresses two genes designated Aeg-1 and Aeg-2, indicating that Aeg- 1 is expressed in both epididymides and SMGs, and that this region may play a role unique to the protein of the male reproductive system.

TL;DR: There appears to be a strong inverse relationship between expression of the GHR and basal plasma GH levels in the prepubertal chicken and the decline in plasma IGF-I lags considerably behind the sharp fall in plasmaGH levels and expression of hepatic IGF- I mRNA during post-hatching development.

TL;DR: Glucagon-like peptide-1 is the main product of the intestinal processing of proglucagon and it is involved at several levels in the regulation of insulin synthesis and secretion.

TL;DR: The elucidation of the complete nucleotide sequences of two types of F. heteroclitus GTH provides definitive proof that in this species there are at least two distinct forms of pituitary GTH analogous to the classical luteinizing hormone-follicle stimulating hormone family.

TL;DR: It was found that estrogen treatment has a positive feedback effect on its own nuclear receptor, in addition to the metabolic effects of estrogen on adipose tissue metabolism.

TL;DR: Results suggest that PRL and GH are involved in regulating AR synthesis, at least partially by direct action on the organ, and IGF-I appears as a paracrine factor playing a role in epithelium/stroma interactions during prostatic development.

TL;DR: Western blot analysis revealed multiple molecular weight forms of sTC within salmon glands, and three sites were identified in the mature protein core of STC that may be acted upon by endopeptidases to produce truncated forms of the hormone.

TL;DR: The sequence data suggest that all of these isoforms contain the putative signal sequence and are derived from a single copy gene via alternative splicing, pointing further to the fact that the expression of the 90 kDa LH/CG receptor is regulated via an extensive alternativesplicing of the receptor gene primary transcript.

TL;DR: The cDNA proved that the cloned gene is expressed in the hypothalamus of mature salmon, and differs extensively in sequence and size from the mammalian counterpart.

TL;DR: These findings further define the location of the heparin and heparan sulfate-binding site of follistatin at the basic amino acid-rich region comprising the amino acid sequence Lys75-Lys-Cys-Arg-Met-Asn- Lys-L Lys-Pro-Arg86.

TL;DR: Characterization of this genomic clone containing exons I.2 and II now establishes the P-450AROM gene to be at least 72 kb in length and raises new questions regarding tissue specific and developmental control of aromatase expression in the human.

TL;DR: Results indicate that a specific subregion (amino acids 704-758) of the carboxy terminal half of the AR is required for the interaction with HSP90.

TL;DR: It is suggested that thyroid hormone stimulates glucose transport by increasing the synthesis of new glucose transporter units and give further evidence for a direct effect of thyroid hormone in the modulation of Sertoli cell functions.