Journal ArticleDOI
Urogenital Challenge of Primate Species with Mycoplasma genitalium and Characteristics of Infection Induced in Chimpanzees
Joseph G. Tully,David Taylor-Robinson,David L. Rose,Patricia M. Furr,Charles E. Graham,Michael F. Barile +5 more
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TLDR
Most chimpanzees colonized with the organism exhibited increased numbers of polymorphonuclear leukocytes in the genital tract and developed a significant antibody response, suggesting the microorganism may have a role in human genital-tract infections.Abstract:
Eighteen male and eight female primates, representing five subhuman species, were inoculated urogenitally with Mycoplasma genitalium, a microorganism recovered from men with nongonococcal urethritis. Male rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) monkeys apparently were resistant. Female squirrel monkeys (Saimiri sciureus) and female tamarins (Saguinus mystax) exhibited low-level, genital-tract infections. Male chimpanzees (Pan troglodytes) developed an obvious genital-tract infection, with some shedding organisms for 21 weeks. M. genitalium was recovered from the blood of two of the male chimpanzees, usually when large numbers of organisms were in the urethra. Female chimpanzees generally shed organisms for 12-15 weeks. Most chimpanzees colonized with the organism exhibited increased numbers of polymorphonuclear leukocytes in the genital tract and developed a significant antibody response. The results offer substantial evidence for the pathogenicity of M. genitalium for the urogenital tract of higher primates and suggest the microorganism may have a role in human genital-tract infections.read more
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Journal ArticleDOI
Mycoplasma genitalium: from Chrysalis to Multicolored Butterfly
TL;DR: The history, replication, genetics, characteristics, and factors involved in the pathogenesis of Mycoplasma genitalium are presented, including adhesion, the influence of hormones, motility, possible toxin production, and immunological responses.
Journal ArticleDOI
Mycoplasmas: sophisticated, reemerging, and burdened by their notoriety.
Joel B. Baseman,Joseph G. Tully +1 more
TL;DR: The biology and pathogenesis of these procaryotes are highlighted and new evidence is provided that may lead to increased appreciation of their role as human pathogens.
Journal ArticleDOI
Mucopurulent cervicitis and Mycoplasma genitalium.
Lisa E. Manhart,Cathy W. Critchlow,King K. Holmes,Susan M. Dutro,David A. Eschenbach,Claire E. Stevens,Patricia A. Totten +6 more
TL;DR: Young age, multiple recent partners, prior miscarriage, smoking, menstrual cycle, and douching were positively associated with M. genitalium, whereas bacterial vaginosis and cunnilingus were negatively associated, suggesting that this organism may be a cause of MPC.
Journal ArticleDOI
Infections Due to Species of Mycoplasma and Ureaplasma: An Update
TL;DR: The determination that a mycoplasma is a cause of disease in patients or animals should be based on the following factors: the isolation rate among patients orAnimals with disease is significantly greater than that among those without disease.
Journal ArticleDOI
Mycoplasma genitalium: the aetiological agent of urethritis and other sexually transmitted diseases
TL;DR: There is very strong evidence that M. genitalium is a cause of NGU in men and cervicitis in women, and antibiotics of the macrolide group appear to be more active than tetracyclines.
References
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Journal Article
Mycoplasma Species Identification Based upon Growth Inhibition by Specific Antisera
TL;DR: In the course of these studies, a PPLO isolated frequently from the normal human pharynx was defined which was distinct from the classified mycoplasma species of human derivation by both the complement fixation and growth inhibition methods.
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A newly discovered mycoplasma in the human urogenital tract.
TL;DR: Although the data are insufficient to implicate the new mycoplasmas in human disease, the fact that they are unique, extremely fastidious, and have adherence properties, has stimulated efforts to assess their pathogenicity and possible role in human urogenital disease.
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A colour test for the measurement of antibody to certain mycoplasma species based upon the inhibition of acid production.
TL;DR: A fermentation-inhibition test for the measurement of growth-inhibiting anti-body to acid-producing mycoplasmas was performed in microtitre plastic plates and showed the inhibitory effect of specific antiserum was much decreased when the horse serum was heat-inacti-vated, indicating the need for a heat-labile accessory factor.
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Enhanced Isolation of Mycoplasma pneumoniae from Throat Washings with a Newly Modified Culture Medium
TL;DR: The findings suggest that these procedures might be effectively applied to the recovery of M. pneumoniae from all likely host and that improved recovery of the organism may aid in the interpretation of a number of puzzling questions about the epidemiology of M., pneumoniae infections.
Journal ArticleDOI
Mycoplasma genitalium, a new species from the human urogenital tract.
TL;DR: It is proposed that mycoplasmas with these characteristics belong to a new species, Mycoplasma genitalium, and G-37 (= ATCC 33530) is the type strain.