D
Doris C. Wong
Researcher at National Institutes of Health
Publications - 35
Citations - 5128
Doris C. Wong is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Hepatitis & Virus. The author has an hindex of 27, co-authored 35 publications receiving 5094 citations.
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Journal ArticleDOI
Lack of protective immunity against reinfection with hepatitis C virus
Patrizia Farci,Harvey J. Alter,Sugantha Govindarajan,Doris C. Wong,Ronald E. Engle,Richard R. Lesniewski,Isa K. Mushahwar,Suresh M. Desai,Roger H. Miller,Norio Ogata,Robert H. Purcell +10 more
TL;DR: Evidence indicates that HCV infection does not elicit protective immunity against reinfection with homologous or heterologous strains, which raises concerns for the development of effective vaccines against HCV.
Journal ArticleDOI
Prevention of Hepatitis C Virus Infection in Chimpanzees by Hyperimmune Serum against the Hypervariable Region 1 of the Envelope 2 Protein
Patrizia Farci,Atsushi Shimoda,Doris C. Wong,Teresa Cabezon,Daniela De Gioannis,Antonello Strazzera,Yohko K. Shimizu,Max Shapiro,Harvey J. Alter,Robert H. Purcell +9 more
TL;DR: It is shown that the hypervariable region 1 (HVR1) of the envelope 2 (E2) protein is a critical neutralization domain of hepatitis C virus and can elicit protective immunity.
Journal ArticleDOI
A Long-Term Study of Hepatitis C Virus Replication in Non-A, Non-B Hepatitis
Patrizia Farci,Harvey J. Alter,Doris C. Wong,Roger H. Miller,James Wai-Kuo Shih,Betsy W. Jett,Robert H. Purcell +6 more
TL;DR: The disappearance of HCV RNA from serum appears to correlate with the resolution of non-A, non-B hepatitis, whereas viremia persists in patients whose disease progresses to chronic hepatitis.
Journal ArticleDOI
Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization.
Patrizia Farci,Harvey J. Alter,Doris C. Wong,Roger H. Miller,Sugantha Govindarajan,Ronald E. Engle,Max Shapiro,Robert H. Purcell +7 more
TL;DR: Experimental evidence in vivo that HCV infection elicits a neutralizing antibody response in humans is provided but it is suggested that such antibodies are isolate-specific, raising concerns for the development of a broadly reactive vaccine against HCV.
Journal ArticleDOI
A colour test for the measurement of antibody to certain mycoplasma species based upon the inhibition of acid production.
TL;DR: A fermentation-inhibition test for the measurement of growth-inhibiting anti-body to acid-producing mycoplasmas was performed in microtitre plastic plates and showed the inhibitory effect of specific antiserum was much decreased when the horse serum was heat-inacti-vated, indicating the need for a heat-labile accessory factor.