Urothelial bladder cancer with cavitary lung metastases.
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TLDR
An unusual case of rapidly metastatic TCC to the lung causing large cavitary masses and nodules is presented, and Imaging performed after the patient began chemotherapy revealed widespread necrosis of the metastatic Cavitary masses causing moderate volume hemoptysis.Abstract:
Transitional cell carcinoma (TCC) of the bladder tends to remain superficial; however, in 5% to 20% of cases, it progresses to muscle invasion and, more rarely, can metastasize. TCC of the bladder primarily spreads via regional lymphatics. The most common sites of distant metastases of TCC are the liver, lung, mediastinum and bone. Longterm survival of patients with metastatic bladder cancer is rare. Patterns of pulmonary metastasis include multiple nodules, a solitary mass or interstitial micronodule. When multiple nodules are present, they are round and well-circumscribed, without calcification or cavitation. An unusual case of rapidly metastatic TCC to the lung causing large cavitary masses and nodules is presented. Imaging performed after the patient began chemotherapy revealed widespread necrosis of the metastatic cavitary masses causing moderate volume hemoptysis.read more
Citations
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HIF-1α promotes ZEB1 expression and EMT in a human bladder cancer lung metastasis animal model.
Jianning Zhu,Zhixin Huang,Mengzhao Zhang,Weiyi Wang,Hua Liang,Jin Zeng,Kaijie Wu,Xinyang Wang,Jer Tsong Hsieh,Peng Guo,Jinhai Fan +10 more
TL;DR: Results from the present study indicate that HIF-1 α promotes ZEB1 expression and EMT in the T24-L human bladder cancer lung metastasis animal model, suggesting that Hif-1α serves an important function in the metastasis of bladder cancer, and HIF -1α and ZEB 1 may be potential targets for inhibiting bladder metastasis in the future.
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The prognostic effect of metastasis patterns on overall survival in patients with distant metastatic bladder cancer: a SEER population-based analysis.
TL;DR: In this paper, the authors investigated the impact of different distant metastases pattern on the survival of patients with stage IV bladder cancers and used multivariable Cox regression models to further analyze survival outcome and other prognostic factors.
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Pulmonary manifestations of urothelial carcinoma of the bladder
Abhinav Agrawal,Sonu Sahni,Abhinav Kumar Vulisha,Rammohan Gumpeni,Rakesh Shah,Arunabh Talwar +5 more
TL;DR: The various pulmonary manifestations of urothelial carcinoma of the bladder include metastatic disease including cavitary lesions, endobronchial, pleural, or lymph node metastasis pleural effusion and chylothorax which can lead to an early diagnosis and assist in instituting an appropriate intervention.
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Pulmonary Metastasis from Urothelial Carcinoma Showing Progressive Multiple Cystic Lesions
Shiro Imokawa,Masahiro Uehara,Tomohiro Uto,Shinya Sagisaka,Jun Sato,Kazumasa Yasuda,Kozo Matsushita,Satoshi Oi,Fumihiko Tanioka,Takafumi Suda,Kingo Chida +10 more
TL;DR: The present case is unusual in that the cystic metastasis had thin, smooth-walled bulla-like features, which has not previously been reported in metastatic urothelial carcinoma.
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Seeding of a high-grade papillary urothelial carcinoma of the bladder along a nephroureterostomy tract.
TL;DR: This case report presents one such unusual outcome where urinary bladder urothelial cancer cells metastasized to the paravertebral soft tissues through apparent seeding along a nephroureterostomy tract.
References
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Superficial Bladder Cancer Metastatic to the Lungs: Two Case Reports and Review of the Literature
TL;DR: The present cases demonstrate isolated pulmonary metastases associated with low-grade superficial bladder cancer, without previous evidence of muscle-invasive disease.
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Locally advanced and metastatic bladder cancer.
TL;DR: There is increasing recognition that in order to achieve tangible improvements in complete response rates and survival in this disease will likely require a combination of chemotherapy and targeted molecular therapies and in some settings adjunctive surgery.
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Cavitary pulmonary metastases in transitional cell carcinoma of urinary bladder.
Journal ArticleDOI
Cavitary pulmonary metastases in transitional cell carcinoma of the urinary bladder.
TL;DR: About 4% of metastases to the lung eventually evolve into cavitary lesions, and the origin of these lesions are squamous cell carcinomas in 69% of cases and adenocarcinomas in the rest.