Figure 1: Figure 1a: The equilibria that exist when [Ru(h6-arene)(5,5’-difluorobipyridine)]+ complexes are incubated in phosphate buffer. Figure 1b: Time course 19F{1H} NMR spectra of complex [4] incubated in 10mM deuterated phosphate buffer (2 mM Ru, pD = 7.2, 310 K). After 24 hr, 1 eq. of AgNO3 was added to abstract the chloride ligand and encourage formation of the aquo complex. Figure 1c: 19F{1H} NMR spectra of complex [2] incubated in D2O and buffered D2O of different phosphate concentration (2 mM Ru, pD = 7.2 (when buffered), 2 hr, 310 K). Figure 1d: Mass spectra recorded of the solution mixture when complex [2] is incubated in D2O and buffered D2O, expected masses quoted in Table S6.
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