An abnormality of sodium handling has been suggested as one of the mechanisms responsible for the development of pregnancy-induced hypertension We analysed the plasma and urinary concentrations, and the intra-erythrocyte activities of Na and K, and the RBC membrane Na+/K+-ATPase activity of 77 hypertensive and 133 normal pregnant women Umbilical cord blood of infants from 21 hypertensive and 28 control women was studied The Na+/K+-ATPase activity was determined by measuring the inorganic phosphate released by incubation in a reaction medium in the presence and absence of K ions or ouabain The intra-erythrocyte sodium and potassium activities were measured by ion-selective electrode analysis of the haemolysates, after washing the RBCs in 110 mmol/l MgCl2 We found a significant increase in intracellular sodium and a reduction in Na+/K+-ATPase activity in the hypertensive women in comparison with the control subjects during pregnancy No difference was observed in early puerperium Cord blood from infan

Variabilité physiologique des concentrations et des transports érythrocytaires du sodium et du potassium.

Citations

Abnormal membrane cation transport in pregnancy-induced hypertension.