Patent
Variants derived from actriib and uses therefor
TLDR
In this article, the authors provide compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue.Abstract:
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.read more
Citations
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Patent
Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
TL;DR: The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them as discussed by the authors, as well as a detailed discussion of their properties.
Patent
Engineered nucleic acids and methods of use thereof
TL;DR: In this paper, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression are provided. But they do not consider the use of modified messenger RNAs, which are useful to treat or prevent diseases, disorders or conditions.
Patent
Modified polynucleotides for the production of biologics and proteins associated with human disease
Stephane Bancel,Tirtha Chakraborty,Antonin de Fougerolles,Sayda Elbashir,Matthias John,Atanu Roy,Susan Whoriskey,Kristy M. Wood,Paul Hatala,Jason P. Schrum,Kenechi Ejebe,Jeff Lynn Ellsworth,Justin Guild +12 more
TL;DR: The present paper relates to the composition of polynucleotides, primary transcripts, and mmRNA molecules, and methods for their preparation, manufacture, and therapeutic use as mentioned in this paper.
Patent
Delivery and formulation of engineered nucleic acids
TL;DR: In this paper, formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression are provided. But the methods are not suitable for the production of proteins.
Patent
Modified polynucleotides for the production of secreted proteins
Stephane Bancel,Tirtha Chakraborty,Fougerolles Antonin De,Sayda M. Elbashir,Matthias John,Atanu Roy,Susan Whoriskey,Kristy M. Wood,Paul Hatala,Jason P. Schrum,Kenechi Ejebe,Jeff Lynn Ellsworth,Justin Guild +12 more
TL;DR: In this paper, the authors provide compositions, methods, processes, kits and devices for the design, preparation, manufacture and/or formulation of modified mRNA (mmRNA) molecules from primary transcripts.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
Book
Antibodies: A Laboratory Manual
Ed Harlow,David P. Lane +1 more
TL;DR: A second edition of Antibodies: A Laboratory Manual is being published in September 2013, Revised, extended and updated by Edward Greenfield of the Dana-Farber Cancer Center, the material has been recast with extensive new information and new chapters have been added.
Journal ArticleDOI
The CCP4 suite: programs for protein crystallography
TL;DR: The CCP4 (Collaborative Computational Project, number 4) program suite is a collection of programs and associated data and subroutine libraries which can be used for macromolecular structure determination by X-ray crystallography.
Journal ArticleDOI
Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.
TL;DR: Results suggest that GDF-8 functions specifically as a negative regulator of skeletal muscle growth, which is significantly larger than wild-type animals and show a large and widespread increase in skeletal muscle mass.
Monoclonal antibodies and cancer therapy
R. A. Reisfeld,S. Sell +1 more
TL;DR: These proceedings collect papers on the subject of monoclonal antibody, biochemical effects and cancer therapeutic potential of tunicamycin, use of monOClonal antibodies for detection of lymph node metastases, active specific immunotherapy, and applications of monocolonal antibodies to investigations of growth factors.