Journal ArticleDOI
Voriconazole-induced periostitis causing arthralgias mimicking a flare of granulomatosis with polyangiitis.
Heather Gladue,David A. Fox +1 more
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A case of voriconazole-induced periostitis that occurred in a 68-year-old woman with granulomatosis with polyangiitis is described, which may cause severe arthralgias that can mimic a flare of rheumatic diseases.Abstract:
We describe a case of voriconazole-induced periostitis that occurred in a 68-year-old woman with granulomatosis with polyangiitis. Our patient presented with months of severe hip pain limiting her daily activities, which was initially felt to be a flare of her granulomatosis with polyangiitis. However, upon further review, she had an elevated alkaline phosphatase and periostitis on her hip radiograph; voriconazole was held, and within 2 days she had marked improvement in her pain. Although this clinical syndrome is well documented in transplant patients, it is a rare complication in patients with autoimmune disorders. However, it is important because it may cause severe arthralgias that can mimic a flare of rheumatic diseases.read more
Citations
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Journal ArticleDOI
Plasma fluoride level as a predictor of voriconazole induced periostitis in patients with skeletal pain
Woo J. Moon,Erica L. Scheller,Anupam Suneja,Jacob A. Livermore,Anurag N. Malani,Varsha Moudgal,Lisa Kerr,Eric Ferguson,David M. Vandenberg +8 more
TL;DR: High plasma fluoride levels coupled with skeletal pain among patients who are on long-term voriconazole therapy is highly suggestive of periostitis.
Journal ArticleDOI
Voriconazole-induced periostitis: a new rheumatic disorder
TL;DR: Periostitis is increasingly reported and should be considered in patients taking voriconazole who present with bone pain and/or alkaline phosphatase elevation as rheumatologists are likely to be called to see such patients, a review of reported cases was undertaken.
Journal ArticleDOI
Voriconazole-induced periostitis in a patient with overlap syndromes.
TL;DR: A 52-year-old woman with overlap syndrome and interstitial pneumonia underwent immunosuppressive therapy and she was suspected to suffer from pulmonary aspergillosis, and oral voriconazole was initiated, and a rapid elevation of alkaline phosphatase occurred after 4 weeks.
Journal ArticleDOI
An update on drug-induced arthritis.
TL;DR: Recognizing that joint symptoms may, in fact, be drug-related not only saves time and unnecessary investigations but can also prevent needless suffering and morbidity due to late recognition of a drug-induced arthritic condition.
Journal ArticleDOI
Voriconazole-associated soft tissue ossification: an undescribed cause of glenohumeral joint capsulitis.
Meera Raghavan,Alex Hayes +1 more
TL;DR: A case of voriconazole-associated periostitis, capsular and enthesial ossification and glenuhumeral capsulitis in a patient with a hematologic malignancy is presented.
References
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Journal ArticleDOI
The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study.
Livio Pagano,Morena Caira,Anna Candoni,Massimo Offidani,Luana Fianchi,Bruno Martino,Domenico Pastore,Marco Picardi,Alessandro Bonini,Anna Chierichini,Rosa Fanci,Cecilia Caramatti,Rosangela Invernizzi,Daniele Mattei,Maria Enza Mitra,Lorella Melillo,Franco Aversa,Maria Teresa Van Lint,Paolo Falcucci,Caterina Giovanna Valentini,Corrado Girmenia,Annamaria Nosari +21 more
TL;DR: Patients with hematologic malignancies are currently at higher risk of IFI caused by molds than by yeasts, and the incidence of I FI is highest among patients with acute myeloid leukemia.
Journal ArticleDOI
Pulmonary aspergillosis: a clinical update
O.S. Zmeili,Ayman O. Soubani +1 more
TL;DR: A clinical update on the epidemiology, risk factors, clinical presentation, diagnosis and management of the major syndromes associated with pulmonary aspergillosis is provided.
Journal ArticleDOI
Fluoride Excess and Periostitis in Transplant Patients Receiving Long-Term Voriconazole Therapy
Robert A. Wermers,Kay Cooper,Raymund R. Razonable,Paul J. Deziel,Gary M. Whitford,Walter K. Kremers,Thomas P. Moyer +6 more
TL;DR: Voriconzole is associated with painful periostitis, exostoses, and fluoride excess in post-transplant patients with long-term voriconazole use and cessation of vorIconazole therapy led to improvement in pain and reduced fluoride and alkaline phosphatase levels.
Journal ArticleDOI
Reversible skeletal disease and high fluoride serum levels in hematologic patients receiving voriconazole.
Bernhard Gerber,Roman Guggenberger,David A Fasler,Gayathri Nair,Markus G. Manz,Georg Stussi,Urs Schanz +6 more
TL;DR: It is concluded that serum fluoride levels were elevated on average 5-fold above normal levels in hematologic patients receiving voriconazole, and Clinically relevant skeletal disease was associated with renal insufficiency and above 10-fold elevated fluoride levels, and was reversible on termination of vorIconazole treatment.
Journal ArticleDOI
Periostitis secondary to prolonged voriconazole therapy in lung transplant recipients.
T. F. Wang,Tisha Wang,R. Altman,Patricia H. Eshaghian,Joseph P. Lynch,David J. Ross,John A. Belperio,S. Sam Weigt,Rajan Saggar,Aric L. Gregson,B. Kubak +10 more
TL;DR: awareness of this potential syndrome, which manifests as bone pain, elevated serum alkaline phosphatase and a bone scan suggestive of periostitis, is necessary in LT recipients on long‐term voriconazole.