Institution
Harper University Hospital
Healthcare•Detroit, Michigan, United States•
About: Harper University Hospital is a healthcare organization based out in Detroit, Michigan, United States. It is known for research contribution in the topics: Cancer & Population. The organization has 543 authors who have published 477 publications receiving 32656 citations.
Topics: Cancer, Population, Warfarin, Carcinoma, Prostate cancer
Papers published on a yearly basis
Papers
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TL;DR: The Human Microbiome Project Consortium reported the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome as discussed by the authors.
Abstract: The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.
8,410 citations
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TL;DR: An evidence-based intervention resulted in a large and sustained reduction (up to 66%) in rates of catheter-related bloodstream infection that was maintained throughout the 18-month study period.
Abstract: A b s t r ac t A total of 108 ICUs agreed to participate in the study, and 103 reported data. The analysis included 1981 ICU-months of data and 375,757 catheter-days. The median rate of catheter-related bloodstream infection per 1000 catheter-days decreased from 2.7 infections at baseline to 0 at 3 months after implementation of the study intervention (P≤0.002), and the mean rate per 1000 catheter-days decreased from 7.7 at baseline to 1.4 at 16 to 18 months of follow-up (P<0.002). The regression model showed a significant decrease in infection rates from baseline, with incidence-rate ratios continuously decreasing from 0.62 (95% confidence interval (CI), 0.47 to 0.81) at 0 to 3 months after implementation of the intervention to 0.34 (95% CI, 0.23 to 0.50) at 16 to 18 months. Conclusions An evidence-based intervention resulted in a large and sustained reduction (up to 66%) in rates of catheter-related bloodstream infection that was maintained throughout the 18-month study period.
3,844 citations
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TL;DR: Cardiac resynchronization improved quality of life, functional status, and exercise capacity in patients with moderate to severe HF, a wide QRS interval, and life-threatening arrhythmias without proarrhythmia or compromised ICD function.
Abstract: ContextCardiac resynchronization therapy (CRT) through biventricular pacing
is an effective treatment for heart failure (HF) with a wide QRS; however,
the outcomes of patients requiring CRT and implantable cardioverter defibrillator
(ICD) therapy are unknown.ObjectiveTo examine the efficacy and safety of combined CRT and ICD therapy in
patients with New York Heart Association (NYHA) class III or IV congestive
HF despite appropriate medical management.Design, Setting, and ParticipantsRandomized, double-blind, parallel-controlled trial conducted from October
1, 1999, to August 31, 2001, of 369 patients with left ventricular ejection
fraction of 35% or less, QRS duration of 130 ms, at high risk of life-threatening
ventricular arrhythmias, and in NYHA class III (n = 328) or IV (n = 41) despite
optimized medical treatment.InterventionsOf 369 randomized patients who received devices with combined CRT and
ICD capabilities, 182 were controls (ICD activated, CRT off) and 187 were
in the CRT group (ICD activated, CRT on).Main Outcome MeasuresThe primary double-blind study end points were changes between baseline
and 6 months in quality of life, functional class, and distance covered during
a 6-minute walk. Additional outcome measures included changes in exercise
capacity, plasma neurohormones, left ventricular function, and overall HF
status. Survival, incidence of ventricular arrhythmias, and rates of hospitalization
were also compared.ResultsAt 6 months, patients assigned to CRT had a greater improvement in median
(95% confidence interval) quality of life score (–17.5 [–21 to
–14] vs –11.0 [–16 to –7], P =
.02) and functional class (–1 [–1 to –1] vs 0 [–1
to 0], P = .007) than controls but were no different
in the change in distance walked in 6 minutes (55 m [44-79] vs 53 m [43-75], P = .36). Peak oxygen consumption increased by 1.1 mL/kg
per minute (0.7-1.6) in the CRT group vs 0.1 mL/kg per minute (–0.1
to 0.8) in controls (P = .04), although treadmill
exercise duration increased by 56 seconds (30-79) in the CRT group and decreased
by 11 seconds (–55 to 12) in controls (P<.001).
No significant differences were observed in changes in left ventricular size
or function, overall HF status, survival, and rates of hospitalization. No
proarrhythmia was observed and arrhythmia termination capabilities were not
impaired.ConclusionsCardiac resynchronization improved quality of life, functional status,
and exercise capacity in patients with moderate to severe HF, a wide QRS interval,
and life-threatening arrhythmias. These improvements occurred in the context
of underlying appropriate medical management without proarrhythmia or compromised
ICD function.
1,609 citations
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TL;DR: The National Pressure Ulcer Advisory Panel (NPUAP) has revised the definition and stages of pressure injury to incorporate the current understanding of the etiology of pressure injuries, as well as to clarify the anatomical features present or absent in each stage of injury.
Abstract: Our understanding of pressure injury etiology and development has grown in recent years through research, clinical expertise, and global interdisciplinary expert collaboration. Therefore, the National Pressure Ulcer Advisory Panel (NPUAP) has revised the definition and stages of pressure injury. The revision was undertaken to incorporate the current understanding of the etiology of pressure injuries, as well as to clarify the anatomical features present or absent in each stage of injury. An NPUAP-appointed Task Force reviewed the literature and created drafts of definitions, which were then reviewed by stakeholders and the public, including clinicians, educators, and researchers around the world. Using a consensus-building methodology, these revised definitions were the focus of a multidisciplinary consensus conference held in April 2016. As a result of stakeholder and public input, along with the consensus conference, important changes were made and incorporated into the new staging definitions. The revised staging system uses the term injury instead of ulcer and denotes stages using Arabic numerals rather than Roman numerals. The revised definition of a pressure injury now describes the injuries as usually occurring over a bony prominence or under a medical or other device. The revised definition of a Stage 2 pressure injury seeks to clarify the difference between moisture-associated skin damage and injury caused by pressure and/or shear. The term suspected has been removed from the Deep Tissue Pressure Injury diagnostic label. Each definition now describes the extent of tissue loss present and the anatomical features that may or may not be present in the stage of injury. These important revisions reflect the methodical and collaborative approach used to examine the available evidence and incorporate current interdisciplinary clinical expertise into better defining the important phenomenon of pressure injury etiology and development.
630 citations
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TL;DR: HGPIN was encountered in 0, 5, 10, 41 and 63% of men in the 3rd, 4th, 5th and 7th decades, respectively, and corresponding figures for invasive carcinoma were 2, 29, 32, 55, and 64% respectively.
Abstract: The relationship of prostatic intraepithelial neoplasia (PIN) and invasive carcinoma of the prostate is not fully understood. It is generally accepted that HGPIN is a probable preinvasive malignant change or at least a marker lesion for carcinoma. The prevalence of HGPIN in younger men is not known. Two hundred and forty nine entirely processed prostates from men aged 20-69 were thoroughly evaluated for the presence of PIN and carcinoma. The histologic diagnosis of all positive cases was confirmed by two pathologists. Our results are summarized as follows: Seventy seven percent of the prostates with HGPIN harbored adenocarcinoma, whereas the frequency of cancer in prostates without HGPIN was 24%. HGPIN was encountered in 0, 5, 10, 41 and 63% of men in the 3rd, 4th, 5th and 7th decades, respectively. The corresponding figures for invasive carcinoma were 2, 29, 32, 55, and 64% respectively.
590 citations
Authors
Showing all 545 results
Name | H-index | Papers | Citations |
---|---|---|---|
Seth M. Steinberg | 137 | 936 | 80148 |
David Smith | 129 | 2184 | 100917 |
Kenneth J. Pienta | 127 | 671 | 64531 |
Harvey I. Pass | 108 | 644 | 47456 |
Jeffrey A. Sosman | 104 | 437 | 91012 |
Jack D. Sobel | 98 | 486 | 61981 |
Cora N. Sternberg | 92 | 663 | 48986 |
David J. Grignon | 78 | 301 | 23119 |
Marcelo F. Di Carli | 75 | 397 | 21418 |
Esther Oliva | 74 | 426 | 17790 |
Edward M. Messing | 72 | 420 | 20754 |
Harry T. Chugani | 71 | 374 | 19699 |
Kim Margolin | 68 | 319 | 23893 |
E. Mark Haacke | 63 | 343 | 17830 |
James W. Mier | 63 | 215 | 16077 |