Journal ArticleDOI
Was it an ancient gene codifying for a hairpin RNA that, by means of direct duplication, gave rise to the primitive tRNA molecule?
TLDR
Analysis of ancestral sequences of the primitive tRNA molecule seems to indicate that self-alignment of these sequences makes it possible for the 3′-half of the reconstructed molecule to display a significant similarity to the 5′- half, indicating that the two halves of tRNA might be paralogous.About:
This article is published in Journal of Theoretical Biology.The article was published on 1995-11-07. It has received 59 citations till now. The article focuses on the topics: Transfer RNA & Small hairpin RNA.read more
Citations
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Journal ArticleDOI
Evolution of the genetic code.
TL;DR: Findings on the genetic code provide empirical evidence, from a contemporaneous source, that a surface reaction network, centred on C-fixing autocatalytic cycles, rapidly led to cellular life on Earth.
Journal ArticleDOI
The origin of the tRNA molecule: implications for the origin of protein synthesis
TL;DR: The model postulates that this molecule originated simply by direct duplication (and subsequent evolution) of a gene coding for an RNA hairpin structure, which can thus be hypothesized as the evolutionary precursor of the tRNA molecule.
Journal ArticleDOI
The non-monophyletic origin of the tRNA molecule and the origin of genes only after the evolutionary stage of the last universal common ancestor (LUCA).
TL;DR: It is shown that some tRNA genes are completely separate in two minigenes codifying for the 5' and 3' halves of this molecule, which proves a non-monophyletic origin for t RNA genes, as a monophyletics origin would exclude the existence of these genes which have, on the contrary, been observed.
Journal ArticleDOI
tRNA Creation by Hairpin Duplication
TL;DR: It is found that actual tRNAs have significantly more matches between the two halves than do random sequences that can form the tRNA structure, and the hypothesis that the modern tRNA cloverleaf arose from a single hairpin duplication prior to the divergence of modern t RNA specificities and the three domains of life is supported.
Journal ArticleDOI
Coevolution Theory of the Genetic Code at Age Forty: Pathway to Translation and Synthetic Life
TL;DR: Coevolution of the genetic code with amino acid biosynthesis generated tRNA paralogs that identify a last universal common ancestor (LUCA) of extant life close to Methanopyrus, which in turn points to archaeal tRNA introns as the most primitive introns and the anticodon usage of Methanipyrus as an ancient mode of wobble.
References
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Journal ArticleDOI
Improved tools for biological sequence comparison.
TL;DR: Three computer programs for comparisons of protein and DNA sequences can be used to search sequence data bases, evaluate similarity scores, and identify periodic structures based on local sequence similarity.
Book
PAUP* 4.0 : Phylogenetic Analysis Using Parsimony
TL;DR: PAUP* 4.0 Beta is a major upgrade of the bestselling software for the inference of evolutionary trees, for use in Macintosh or Windows/DOS-based formats.
Book ChapterDOI
Rapid and Sensitive Sequence Comparison with FASTP and FASTA.
TL;DR: FASTA and FASTP were designed to identify protein sequences that have descended from a common ancestor and they have proved very useful for this task, but it is not clear that NWS-based programs would be more successful in finding distantly related members of the G-protein-coupled receptor family.