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Antibacterial activity of ZnO due to change in concentration of ZnO? 


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The antibacterial activity of zinc oxide nanoparticles (ZnO NPs) is influenced by the concentration of ZnO. Different concentrations of ZnO NPs were tested against various bacterial cell densities, and the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined . The rate of antibiotic activity of ZnO NPs depends on the size and concentration of the nanoparticles . ZnO NPs exhibited antibacterial efficacy against Staphylococcus aureus, with zones of inhibition and MIC values varying based on the size and concentration of the nanoparticles . The antimicrobial action of ZnO NPs is not dependent on intra-bacterial internalization, as both nano- and microscale particles showed comparable antibacterial efficacy . The bactericidal mechanism of ZnO NPs involves the release of highly reactive oxygen species (ROS) from the nanoparticle surface, which can damage the cell wall, cell membrane, DNA, and proteins of the bacteria .

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The antibacterial activity of ZnO nanoparticles (ZnO NPs) was evaluated at concentrations ranging from 0.2 to 1.4 mM. Sensitivity was observed at 0.6 mM for Gram-negative bacteria and 1.0 mM for Gram-positive bacteria.
The antibacterial activity of ZnO nanoparticles (NPs) against Enterotoxigenic Staphylococcus aureus improved with an increase in the concentration of ZnO NPs, as mentioned in the paper.
Open accessJournal ArticleDOI
Kavita Kalra, V. Chhabra, N. Prasad 
01 May 2022-Journal of physics
4 Citations
The paper mentions that the rate of antibiotic activity of ZnO NPs depends on the concentration of ZnO NPs, suggesting that the antibacterial activity of ZnO may change with different concentrations.
The paper states that the concentration of total protein in E. coli O26 decreased as the concentration of ZnO NPs increased, indicating a change in bacterial activity with varying ZnO NPs concentration.

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