Are there any data on Schwann cells and antigen presentation?
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Schwann cells have been shown to have antigen-presenting capabilities and can function as professional antigen presenting cells (APCs) . They express MHC class II (MHC-II) molecules and can present antigens to T helper cells, promoting post-traumatic axonal loss and neuropathic pain . Schwann cells also have the ability to up- and down-regulate immunomodulatory molecules, including receptors, and actively respond to both foreign and autoantigens . Additionally, Schwann cells have been found to participate in crosstalk with immune cells in peripheral nerve pathologies, suggesting a broader role in immune responses and inflammatory processes . Overall, the data from these studies indicate that Schwann cells play a significant role in antigen presentation and immune modulation in the peripheral nervous system.
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| Papers (5) | Insight |
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35 Citations | Yes, the paper mentions data on Schwann cell's role in presenting antigens. |
| Yes, the paper states that Schwann cells have the capacity to act as antigen-presenting cells and modulate immune responses in nerve. | |
| Yes, the paper provides data on Schwann cells and antigen presentation. The study shows that human repair-related Schwann cells (hrSCs) function as professional antigen presenting cells and express co-regulatory molecules required for T-cell activation and inhibition. | |
44 Citations | The paper provides experimental evidence that Schwann cells gain antigen-presenting function in vivo and modulate local immune responses in the peripheral nerves. |
08 Mar 2022 | The paper provides data on the immunomodulatory capacities of human repair-related Schwann cells (hrSCs), suggesting that hrSCs function as professional antigen presenting cells in vitro. |
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