Are there any differeneces in the electrophysiological properties of old and young mice?
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Old and young mice exhibit differences in their electrophysiological properties. Aging affects the electroencephalography (EEG) features, with old mice showing longer immobility times under midazolam administration compared to young mice . In aged mice, there is an increase in the incidence of cardiac hypertrophy and fibrosis, leading to a higher susceptibility to ventricular arrhythmias . Senescence-induced changes in neuronal activity at the network level are observed in aged mice, impacting awake/sleep states and potentially leading to pathological symptoms associated with sleep disturbance . Furthermore, young mice before puberty exhibit different neural sensitivity to maximal electroshock seizure (MES) compared to older mice, emphasizing the importance of considering developmental stages in electrophysiological examinations .
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| Papers (5) | Insight |
|---|---|
| Yes, aged mice show weaker representation of awake/sleep states in local field potentials compared to young mice. Enriched environment housing can improve the representation of these states in aged mice. | |
6 Citations | Old mice showed increased action potential duration, Ca2+ transient duration, and slowed ventricular conduction compared to young mice. Additionally, old mice exhibited higher susceptibility to ventricular arrhythmias. |
| Yes, aged mice show weaker representation of awake/sleep states in local field potentials compared to young mice, indicating altered neuronal network activity with age. | |
| Old mice exhibited longer immobility under midazolam. Both age groups showed decreased δ, θ, and α power with increased β and γ power. Old mice had lower γ power, indicating aging effects. | |
4 Citations | Yes, young mice before puberty showed varying sensitivity to maximal electroshock seizures compared to older mice, indicating distinct electrophysiological differences among different developmental stages. |
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