Blood-brain barrier and ephytelial intestinal barrier dysfunction: ¿does it is a common point in psychiatric disorders?
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The blood-brain barrier (BBB) is a crucial component of the central nervous system (CNS) that regulates the passage of substances and immune cells between the blood and the brain . BBB disruption has been associated with the onset and progression of major neurological disorders . Major depression, a prevalent psychological disease, has also been linked to BBB disruption, which contributes to increased susceptibility to depression . The BBB is a specialized multicellular structure that requires coordinated interactions between various CNS cell types and structures, known as the neurovascular unit (NVU) . BBB dysfunction has been observed in several disease states, including schizophrenia, epilepsy, traumatic brain injury, autism, and DiGeorge syndrome . Methamphetamine abuse can cause structural or functional abnormalities of the BBB, increasing the risk of neurodegenerative diseases . While the relationship between blood-brain barrier and epithelial intestinal barrier dysfunction in psychiatric disorders is not explicitly addressed in the provided abstracts, the role of BBB dysfunction in psychiatric disorders is highlighted.
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| Papers (5) | Insight |
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01 May 2023 | The provided paper does not discuss the relationship between blood-brain barrier dysfunction and psychiatric disorders. |
| The provided paper discusses the blood-brain barrier dysfunction in several disease states, including schizophrenia. However, it does not mention anything about the dysfunction of the epithelial intestinal barrier or its association with psychiatric disorders. | |
16 Mar 2021 | The provided paper does not discuss the relationship between blood-brain barrier dysfunction and psychiatric disorders. |
37 Citations | The provided paper does not discuss the relationship between blood-brain barrier dysfunction and psychiatric disorders. The paper focuses on the structure and function of the blood-brain barrier in both healthy and altered/diseased conditions, as well as potential therapeutic targets for restoring its integrity in brain disorders. |
19 Citations | The provided paper does not discuss the relationship between blood-brain barrier dysfunction and epithelial intestinal barrier dysfunction in psychiatric disorders. |
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