Can autophagy remove cysts?
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| As the damaged proximal tubular cells with intracellular vacuoles form cysts later, we postulated that autophagy may play a role in the cyst formation and examined autophagy activity before and after cyst development in AQP11(−/−) kidneys. | |
| These results suggest the involvement of autophagy in the development and maintenance of kidney cysts in AQP11(−/−) mice. | |
22 Citations | Abnormal autophagy may lead to tumorigenesis. |
145 Citations | As such, autophagy is tumor suppressive. |
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