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Can free free liposomes support the growth of intracellular bacteria inside host cells?

Host cell membrane

Lipid biosynthesis

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Free liposomes, without any encapsulated antibiotic, do not support the growth of intracellular bacteria inside host cells. Research indicates that liposomal encapsulation of antibiotics, such as ampicillin, enhances antibacterial activity against intracellular bacteria. In contrast, studies show that liposomes can be utilized to deliver antibiotics effectively to intracellular bacterial pools, improving antibacterial activity. Furthermore, liposomes functionalized with specific moieties, like extracellular adherence protein (Eap), can facilitate the intracellular delivery of antibiotics, reducing intracellular bacterial load. Therefore, while free liposomes alone do not promote the growth of intracellular bacteria, they can be instrumental in enhancing the delivery and efficacy of antibiotics against intracellular infections.

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Open access•Journal Article•DOI Effect of liposome-entrapped ampicillin on survival of Listeria monocytogenes in murine peritoneal macrophages. Irma A. J. M. Bakker-Woudenberg, A. F. Lokerse, J. C. Vink-Van Den Berg, Fh Roerdink, Marc F. Michel - Show less +4 more 01 Aug 1986-Antimicrobial Agents and Chemotherapy 48 Citations	Empty liposomes do not support the growth of intracellular bacteria inside host cells. They had no effect on bacterial growth, indicating they do not promote intracellular bacterial survival.
Open access•Journal Article•DOI Bioinspired Liposomes for Oral Delivery of Colistin to Combat Intracellular Infections by Salmonella enterica Sara Menina, Janina Eisenbeis, Mohamed Ashraf M. Kamal, Marcus Koch, Markus Bischoff, Sarah Gordon, Brigitta Loretz, Claus-Michael Lehr - Show less +7 more 01 Sep 2019-Advanced Healthcare Materials 37 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Cell-Free Phospholipid Biosynthesis by Gene-Encoded Enzymes Reconstituted in Liposomes. Andrew Scott, Marek J. Noga, Paul de Graaf, Ilja Westerlaken, Esengül Yildirim, Christophe Danelon - Show less +5 more 06 Oct 2016-PLOS ONE 89 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Polymer-augmented liposomes enhancing antibiotic delivery against intracellular infections. Fang-Yi Su, Jasmin Chen, Hye-Nam Son, Abby M. Kelly, Anthony J. Convertine, T. Eoin West, Shawn J. Skerrett, Daniel M. Ratner, Patrick S. Stayton - Show less +8 more 25 Jun 2018-Biomaterials Science 41 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Functionalised liposomal formulations for delivery of antibiotic agents Rosa Catania, Oran Maguire, Christopher I. Moore, Franco H. Falcone, Weng Chan, Giuseppe Mantovani, Snow Stolnik, Alan Huett - Show less +7 more 01 Mar 2019 3 Citations	Not addressed in the paper.

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