Can high blood glucose affect immune response?
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High blood glucose levels have been shown to negatively impact immune responses. In conditions like Type 2 Diabetes, hyperglycemia can lead to immune dysfunction, making individuals more susceptible to infections. Studies have demonstrated that high glucose levels inhibit immune responses mediated by specific pathways, such as the SKN-1 pathway, exacerbating infections and decreasing survival rates. Additionally, chronic exposure to high glucose can activate various signaling pathways that promote cancer progression and impair immune responses, increasing susceptibility to viral infections. Interestingly, different mouse strains have shown varying immune responses to hyperglycemia, with some being more sensitive to its deleterious effects than others. Understanding these mechanisms is crucial for developing treatments to mitigate the impact of high blood glucose on immune function.
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| Papers (5) | Insight |
|---|---|
423 Citations | High blood glucose in Type 2 Diabetes can impair immune response, making diabetic individuals more susceptible to infections due to immune dysfunction caused by hyperglycemia. |
10 Oct 2022 4 Citations | High blood glucose impairs immune response by dysregulating ROS formation, altering ETC and glutaminolysis, making hyperglycemic patients more susceptible to viral infections. |
15 Nov 2018 | High blood glucose negatively affects immune response by inhibiting the SKN-1-mediated innate immunity in C. elegans, leading to increased infection susceptibility and decreased survival rates. |
| High blood glucose can affect the immune response, as shown in the study where hyperglycemia decreased immune response in BALB/cByJ mice but not in C57Bl/6J mice due to oxidative stress. | |
8 Citations | High blood glucose does not affect antigen-specific activation and cytolytic killing by CD8+ T cells in vivo, as shown in the study. |
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