F
F. Susan Wong
Researcher at Cardiff University
Publications - 141
Citations - 8674
F. Susan Wong is an academic researcher from Cardiff University. The author has contributed to research in topics: NOD mice & Cytotoxic T cell. The author has an hindex of 41, co-authored 129 publications receiving 7778 citations. Previous affiliations of F. Susan Wong include Millennium Pharmaceuticals & Yale University.
Papers
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Journal ArticleDOI
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Li Wen,Ruth E. Ley,Ruth E. Ley,Pavel Volchkov,Peter B. Stranges,Lia Avanesyan,Austin C. Stonebraker,Changyun Hu,F. Susan Wong,Gregory L. Szot,Jeffrey A. Bluestone,Jeffrey I. Gordon,Alexander V. Chervonsky +12 more
TL;DR: It is found that MyD88 deficiency changes the composition of the distal gut microbiota, and that exposure to the microbiota of specific pathogen-free MyD 88-negative NOD donors attenuates T1D in germ-free NOD recipients.
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The Role of Fas in Autoimmune Diabetes
Alexander V. Chervonsky,Yi Wang,F. Susan Wong,Irene Visintin,Richard A. Flavell,Richard A. Flavell,Charles A. Janeway,Charles A. Janeway,Louis A. Matis +8 more
TL;DR: Induction of Fas expression on beta cells and their subsequent destruction constitutes the main pathogenic mechanism in autoimmune diabetes.
Journal Article
Role of Fas in Autoimmune Diabetes
Conchi Mora,Li Wen,Ramon Gomis,E. Allison Green,Alexander V. Chervonsky,F. Susan Wong,Ainhoa Garcia,Ricahard A. Flavell +7 more
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Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.
F. Susan Wong,Jaana T. Karttunen,Caroline Dumont,Li Wen,Irene Visintin,Ingrid M. Pilip,Nilabh Shastri,Eric G. Pamer,Charles A. Janeway +8 more
TL;DR: This is the first identification, to the authors' knowledge, of a CD8 T-cell epitope in an autoimmune disease, and the peptide recognized by the cells is in the same region of the insulin B chain as the epitope recognized by previously isolated pathogenic CD4 T cells.
Journal ArticleDOI
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice
Changyun Hu,Daniel Rodriguez-Pinto,Wei Du,Anupama Ahuja,Octavian Henegariu,F. Susan Wong,Mark J. Shlomchik,Li Wen +7 more
TL;DR: It is demonstrated that B cell depletion in mice can prevent or delay diabetes, reverse diabetes after frank hyperglycemia, and lead to the development of cells that suppress disease.