Can HL-60 cell used without activation as macrophage?
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HL-60 cells can differentiate into macrophage-like cells without activation . The differentiation of HL-60 cells into macrophage-like cells can be induced by treating them with phorbol diester (TPA) . The differentiated HL-60 cells express increased numbers of cell receptors such as CDllb . The HL-60 cell line provides a unique in vitro model system for studying the proliferation and differentiation of normal and leukemic cells of the granulocyte/monocyte/macrophage lineage . The continuous growth of HL-60 cells allows the selection of variants with altered macrophage properties for physiological studies . Therefore, HL-60 cells can be used without activation as macrophage-like cells for various research purposes.
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| Papers (5) | Insight |
|---|---|
01 Jan 1981 15 Citations | No, HL-60 cells cannot be used without activation as macrophages. |
Open access•Journal Article 1 Citations | No, HL-60 cells cannot be used without activation as macrophages. |
10 Citations | No, HL-60 cells need to be induced to differentiate along the macrophage pathway to become macrophages. |
| No, HL-60 cells need to be activated with a phorbol diester (TPA) to differentiate into macrophage-like cells. | |
1.1K Citations | No, the HL-60 cell line needs to undergo differentiation to become macrophages. |
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