Can lectin-based assays achieve the same level of sensitivity and accuracy as traditional antibody-based serological tests?
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Lectin-based assays have shown promising potential in achieving comparable sensitivity and accuracy to traditional antibody-based serological tests. Research has demonstrated the use of lectins for detecting antigens, such as lectin-coated nanoparticles for detecting lectins in lateral flow immuno-assays . Additionally, lectin-based glycoprofiling of cancer antigen 15-3 (CA15-3) has shown improved clinical sensitivity in detecting breast cancer compared to conventional immunoassays . Moreover, lectin inhibition of antibody binding has been utilized for glycoform-specific assays, enabling the quantification of glycoproteins like carcinoembryonic antigen with potential applications in cancer diagnosis . These findings collectively suggest that lectin-based assays can offer a viable alternative to antibody-based tests, showcasing comparable levels of sensitivity and accuracy in serological testing.
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24 Citations | Lectin-based assays, specifically CA15-3WGA and CA15-3MGL, show improved sensitivity and accuracy compared to traditional CA15-3 immunoassays for detecting breast cancer-associated glycovariants in human plasma. |
7 Citations | Yes, lectin-based assays can achieve comparable sensitivity to traditional antibody-based tests, as shown in lateral flow glyco-assays detecting lectins at subnanomolar concentrations, akin to antibody systems. |
| Lectin-based assays, utilizing glyconanoparticles, show potential for sensitivity and accuracy comparable to traditional antibody-based serological tests, as demonstrated in the study. | |
1 Citations | Lectin-based assays, like ELLA-NI, can achieve high sensitivity and accuracy comparable to traditional antibody-based serological tests, as validated in the study for quantifying anti-NA antibodies. |
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