Can m7G base pair with cytosine?
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Yes, N7-methylguanine (N7mG) can base pair with cytosine. The calculations predict that N7mG would preferentially pair with cytosine during DNA replication, similar to the canonical G:C base pair . The stability of the N7mG:C1 base pair is found to be energetically more stable than other base pairs studied . Additionally, the preferred hydration sites of the guanine-cytosine (GC) pair make around five hydrogen bonds with water, indicating the presence of a stable interaction . The protonation of the guanine-cytosine (GC) base pair also strengthens the interstrand hydrogen bonds, suggesting a stable interaction . Therefore, based on the computational simulations and analysis, it can be concluded that N7mG can form stable base pairs with cytosine .
Answers from top 4 papers
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| Papers (4) | Insight |
|---|---|
| The provided paper does not mention anything about m7G base pairing with cytosine. | |
| The provided paper does not mention m7G or its ability to base pair with cytosine. | |
| The provided paper does not mention anything about m7G base pairing with cytosine. | |
| The paper does not mention m7G, it only discusses N7-methylguanine (N7mG). Therefore, there is no information in the paper about whether m7G can base pair with cytosine. |
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