Cannabinoids and terpenes can promote apoptosis in cancer cells
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Cannabinoids and terpenes have shown promising potential in promoting apoptosis in cancer cells, including colorectal cancer (CRC). Studies have indicated that cannabinoids, through the activation of CB1/2 receptors, can suppress cell proliferation, clonogenicity, and induce proapoptotic functions in various cancer types, such as pancreatic and breast cancer. Additionally, cannabinoids have been found to exert antiproliferative, apoptotic, and anti-migratory effects on cancer cells by modulating various signaling pathways. Furthermore, research on CRC cells has demonstrated that CB2 agonists induce apoptosis by upregulating pro-apoptotic genes like Caspase-3 and p53, while downregulating anti-apoptotic Bcl-2, ultimately leading to cell death. Overall, cannabinoids and terpenes from Cannabis sativa exhibit significant potential in promoting apoptosis in cancer cells, highlighting their possible therapeutic benefits in cancer treatment.
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| Papers (5) | Insight |
|---|---|
| Cannabinoids have shown to promote apoptosis in cancer cells, as per the study. However, the role of terpenes in promoting apoptosis in cancer cells is not addressed in the paper. | |
| Yes, cannabinoids, specifically CB2 agonists, induce apoptosis in colorectal cancer cells by upregulating caspase-3 and p53 while downregulating Bcl-2, suggesting potential for cancer treatment. | |
| Yes, cannabinoids and terpenes from Cannabis sativa can promote apoptosis in colorectal cancer cells, indicating their potential as antitumor agents in cancer therapy. | |
| Cannabinoids, specifically CB1/2 agonists, induce apoptosis in pancreatic and breast cancer cells, as shown in the study. The role of terpenes in promoting apoptosis is not addressed in the paper. | |
| Cannabinoids can induce apoptosis in cancer cells through various signaling pathways, as highlighted in the research. Terpenes' role in promoting apoptosis is not specifically addressed in the paper. |
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