Do tip cells depend on VEGF-A distribution or VEGF-A isoform distribution?
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Tip cells depend on both VEGF-A distribution and VEGF-A isoform distribution. The spatial distribution of VEGF-A, controlled by alternative splicing and proteolysis, plays a key role in VEGF diffusion and gradients in tissues . VEGF-A concentration and gradients are critical parameters in determining tip/stalk patterning . Additionally, VEGF-A induces the tip cell phenotype and is involved in tip cell selection . The presence of elevated VEGF-A affects the onset conditions and equilibrium spacing of tip-stalk patterns . Furthermore, tip cells exhibit hallmarks of tip cells, including filopodia-like extensions and elevated mRNA levels of known tip cell genes, in response to VEGF stimulation . Therefore, both VEGF-A distribution and VEGF-A isoform distribution are important factors in determining the behavior and function of tip cells in angiogenic sprouting.
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| Papers (5) | Insight |
|---|---|
| Tip cells depend on VEGF-A distribution. | |
256 Citations | The paper does not mention the dependence of tip cells on VEGF-A distribution or VEGF-A isoform distribution. |
Open access•Dissertation 18 Aug 2014 1 Citations | The paper does not specifically mention whether tip cells depend on VEGF-A distribution or VEGF-A isoform distribution. |
| Tip cells depend on VEGF-A isoform distribution. | |
253 Citations | Tip cells depend on VEGF-A distribution, not VEGF-A isoform distribution. |
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