H
Holger Gerhardt
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 177
Citations - 28897
Holger Gerhardt is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Angiogenesis & Endothelial stem cell. The author has an hindex of 67, co-authored 169 publications receiving 25130 citations. Previous affiliations of Holger Gerhardt include Lincoln's Inn & London Research Institute.
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Journal ArticleDOI
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Holger Gerhardt,Matthew Golding,Marcus Fruttiger,Christiana Ruhrberg,Andrea Lundkvist,Alexandra Abramsson,Michael Jeltsch,Christopher A. Mitchell,Kari Alitalo,David T. Shima,Christer Betsholtz +10 more
TL;DR: It is shown here that VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts.
Journal ArticleDOI
Basic and Therapeutic Aspects of Angiogenesis
TL;DR: The emerging principles of vascular growth provide exciting new perspectives, the translation of which might overcome the current limitations of pro- and antiangiogenic medicine.
Journal ArticleDOI
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
Mats Hellström,Li-Kun Phng,Jennifer J. Hofmann,Elisabet Wallgard,Leigh Coultas,Per Lindblom,Per Lindblom,Jackelyn A. Alva,Ann Katrin Nilsson,Linda Karlsson,Nicholas Gaiano,Keejung Yoon,Janet Rossant,M. Luisa Iruela-Arispe,Mattias Kalén,Holger Gerhardt,Christer Betsholtz +16 more
TL;DR: Evidence is presented that delta-like 4 (Dll4)–Notch1 signalling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina, and modulators of Dll4 or Notch signalling, such as γ-secretase inhibitors developed for Alzheimer's disease, might find usage as pharmacological regulators of angiogenesis.
Journal ArticleDOI
Role of PFKFB3-Driven Glycolysis in Vessel Sprouting
Katrien De Bock,Maria Georgiadou,Sandra Schoors,Anna Kuchnio,Brian W. Wong,Anna Rita Cantelmo,Annelies Quaegebeur,Bart Ghesquière,Sandra Cauwenberghs,Guy Eelen,Li-Kun Phng,Inge Betz,Bieke Tembuyser,Katleen Brepoels,Jonathan Welti,Ilse Geudens,Inmaculada Segura,Bert Cruys,Franscesco Bifari,Ilaria Decimo,Raquel Blanco,Sabine Wyns,Jeroen Vangindertael,Susana Rocha,Russel T Collins,Sebastian Munck,Dirk Daelemans,Hiromi Imamura,Roland Devlieger,Mark H. Rider,Paul P. Van Veldhoven,Frans Schuit,Ramon Bartrons,Johan Hofkens,Peter Fraisl,Sucheta Telang,Ralph J. DeBerardinis,Luc Schoonjans,Stefan Vinckier,Jason Chesney,Holger Gerhardt,Holger Gerhardt,Mieke Dewerchin,Peter Carmeliet +43 more
TL;DR: It is shown that ECs relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the gly colytic activator PFKFB3 in ECs impaired vessel formation.
Journal ArticleDOI
Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis.
Mats Hellström,Holger Gerhardt,Holger Gerhardt,Mattias Kalén,Xuri Li,Ulf Eriksson,Hartwig Wolburg,Christer Betsholtz +7 more
TL;DR: Although PC deficiency appears to have direct effects on EC number before E 13.5, the subsequent increased VEGF-A levels may further abrogate microvessel architecture, promote vascular permeability, and contribute to formation of the edematous phenotype observed in late gestation PDGF-B and PDGFR-beta knock out embryos.