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Does caffeine affect gential system of rats?

Ovarian follicle

Cerebellar cortex

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Caffeine consumption during pregnancy has adverse effects on the reproductive system of rat offspring, including the ovary. High-dose caffeine exposure during gestation leads to a decrease in the weight, volume, and number of follicles in the ovary, as well as a reduction in the thickness of the zona pellucida. It also affects the development of different types of follicles, including primary, secondary, and Graafian follicles. The mean volume of the oocyte in Graafian follicles is significantly reduced in caffeine-treated groups. However, in a study on diabetic rats, moderate doses of caffeine did not have a damaging effect on the skeletal system. Another study found that caffeine modified the global power of brain activity and the number of peaks in the EEG trace, as well as the percentage of different brain waves. There is no specific information in the provided abstracts about the direct effects of caffeine on the genital system of rats.

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Journal Article•DOI Caffeine and Cannabis Effects on the Cerebellar Cortex of Juvenile Rats J. O. Owolabi, S.Y. Olatunji, A Olanrewaju, P. U. Abu - Show less +3 more 10 Jan 2017-Journal of Advances in Biology & Biotechnology	The provided information does not mention any effects of caffeine on the genital system of rats.
Journal Article•DOI The effects of caffeine on ovarian tissue in rats Maryam Yadegari Dehnavi, Aghdas Mirjalili, Hengameh Dortaj, Abolghasem Abbasi Sarcheshmeh, Fatemeh Zare Mehrjerdi - Show less +4 more 01 Feb 2021-Naunyn-schmiedebergs Archives of Pharmacology	Yes, high-dose caffeine consumption during gestation affects all stages of ovarian follicle development in rat offspring.
Open access•Journal Article The effect of caffeine on cerebral asymmetry in rats. M Voiculescu, A Segărceanu, Negutu M, Isabel Ghita, Ion Fulga, Oana Andreia Coman - Show less +5 more 01 Oct 2015-Journal of medicine and life 3 Citations	The given text does not provide any information about the effect of caffeine on the genital system of rats.
Open access•Journal Article•DOI Caffeine at a Moderate Dose Did Not Affect the Skeletal System of Rats with Streptozotocin-Induced Diabetes. Joanna Folwarczna, Aleksandra Janas, Urszula Cegieła, Maria Pytlik, Leszek Śliwiński, Magdalena Matejczyk, Anna Nowacka, Karolina Rudy, Zora Krivošíková, Stefíková K, Martin Gajdoš - Show less +10 more 30 Oct 2017-Nutrients 14 Citations	The text does not provide any information about the effects of caffeine on the genital system of rats.

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