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Does creatine stop autophagy?

Programmed cell death

Protein degradation

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Journal Article•DOI Protein turnover via autophagy: implications for metabolism. Noboru Mizushima, Daniel J. Klionsky - Show less +1 more 07 Aug 2007-Annual Review of Nutrition 745 Citations	Under these conditions, autophagy may become essential for viability.
Open access•Journal Article•DOI CREG1 ameliorates myocardial fibrosis associated with autophagy activation and Rab7 expression. Chenghui Yan, Yang Li, Xiaoxiang Tian, Nan Zhu, Hai-xu Song, Jian Zhang, Mingyu Sun, Yaling Han - Show less +7 more 01 Feb 2015-Biochimica et Biophysica Acta 27 Citations	These findings suggest that autophagy activation via CREG1 may be a viable therapeutic strategy autophagy for improving cardiac performance under pathologic conditions.
Journal Article•DOI Creatine Is an Ergogen for Anaerobic Exercise Steven M. Toler 27 Apr 2009-Nutrition Reviews 16 Citations	There appears to be scientific merit to the claim that creatine is ergogenic when taken in large amounts.

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Does creatine work?5 answersCreatine supplementation has been shown to have positive effects on exercise and sports performance, including increases in maximal strength, power production, sprint performance, and fat-free mass. It can also speed up recovery time between bouts of intense exercise by mitigating muscle damage and promoting faster recovery. However, there are contradictory findings regarding the potential ergogenic benefits of creatine during endurance-type exercise and in activities where an increase in body mass may hinder performance. Creatine supplementation can enhance glycogen resynthesis and content, lower inflammation and oxidative stress, and potentially increase mitochondrial biogenesis, which may contribute to improved endurance performance. Additionally, creatine has been found to play key roles in the brain, including buffering energy supply, improving mitochondrial efficiency, acting as an anti-oxidant, and acting as a neuroprotectant. Studies have consistently shown that creatine supplementation is safe and well tolerated in healthy individuals and in various patient populations. Early clinical trials also indicate that creatine may have efficacy as an antidepressant agent.

What are the effects of creatine on health?5 answersFoi demonstrado que a suplementação de creatina tem vários efeitos na saúde. Pode aumentar a capacidade de energia anaeróbica, a síntese protéica e a massa muscular, levando a um melhor desempenho físico. A creatina também pode ter benefícios terapêuticos potenciais para condições como diabetes, sarcopenia, osteoporose, câncer, reabilitação e saúde pulmonar e cardiovascular. Além disso, a creatina tem se mostrado promissora na atenuação dos sintomas de concussão, lesão cerebral traumática leve e depressão. Também foi descoberto que desempenha um papel crítico no metabolismo celular e pode melhorar a recuperação de lesões e controlar doenças crônicas. Além disso, a creatina exibe efeitos antioxidantes e antiinflamatórios e pode ter potencial como terapia adjuvante para a saúde cardiovascular. No geral, descobriu-se que a suplementação de creatina tem vários benefícios terapêuticos e de saúde ao longo da vida.

Does creatine affect HRT?5 answersCreatine is not mentioned in any of the provided abstracts, therefore there is no information available to suggest whether or not creatine affects hormone replacement therapy (HRT).

What is the effect of creatine?4 answersCreatine has various effects on the body. It has been found to positively influence the growth and elongation of plants in vitro. In terms of human health, creatine supplementation has been shown to have several benefits, including promoting general health as we age and aiding in recovery from injury and management of chronic disease. Additionally, creatine has been studied for its potential neuroprotective effects and its ability to diminish the harmful effects of peripheral nerve injury. In the context of exercise, creatine supplementation has been shown to transiently increase arterial stiffness after high-intensity resistance exercise. Overall, creatine has a wide range of effects on plants, human health, and exercise performance.

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