Does dilution of active material with water considered pharmaceutical?
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Yes, dilution of active pharmaceutical ingredients with water is a common practice to improve solubility. This is particularly important for compounds with poor aqueous solubility, as dilution from organic solvents to aqueous solutions can enhance the bioavailability of the drug. The process of dilution can lead to the formation of colloids or nanoparticles, impacting the stability and dispersion of the active ingredients. Excipients play a crucial role in this process, as they can interact with the drugs in the dosage form, affecting their solubility and absorption. Therefore, understanding the mechanisms of drug-excipient interactions during dilution is essential for designing effective formulations. Dilution with water is a key step in pharmaceutical formulation development, influencing the solubility, stability, and bioavailability of the active pharmaceutical ingredients .
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15 Citations | Dilution of active material with water is common in pharmaceutical practice, but the study highlights the importance of characterizing metal-based drug candidates in aqueous solutions to avoid uncertainties. |
01 Jan 2017 2 Citations | Dilution of active material with water is a crucial pharmaceutical consideration for solubility enhancement in dosage forms, as discussed in the study on drug-excipient interactions. |
Patent 11 Aug 2008 4 Citations | Upon dilution in an aqueous medium, the delivery system in the paper forms non-ionic surfactant nanoparticles, aiding in solubilizing water-insoluble pharmaceutical active ingredients, thus making it pharmaceutical. |
| Not addressed in the paper. | |
Patent 09 Aug 2007 1 Citations | Dilution of the active material with water to form a dispersion of non-ionic surfactant nanoparticles is a pharmaceutical process discussed in the paper. |
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